Research Scientist Senior

RESEARCH SCIENTIST SENIOR

The Volpicelli‑Daley lab at the University of Alabama at Birmingham is seeking a senior researcher in the pathobiology and structural biology of protein aggregation in Parkinson’s disease. This position offers unique networking, career building, and presentation opportunities.

• Oversee substantial research projects, ensuring rigorous scientific standards.
• Manage project scope, cross‑functional collaboration, and secure funding through grant proposals.
• Exercise discretion in research decisions and shape the research agenda.
• Depending on the research focus, engage with collaborators, research animals, and specimens.

• Express and purify alpha‑synuclein using fast performance liquid chromatography and perform quality controls.
• Troubleshoot and optimize alpha‑synuclein amplification assays.
• Assist with biochemical and biophysical assays to assess alpha‑synuclein fibril structure.
• Design experiments in collaboration with Dr. Volpelli‑Daley.
• Collect, store, and analyze data in an organized manner, maintaining e‑notebooks regularly.
• Supervise graduate students and Scientist I who help with the project.
• Perform other duties as assigned.

• Experience with protein purification.
• Experience with tissue and cell fractionation techniques.
• Experience with chaperones related to alpha‑synuclein and tau fibrillization.
• Experience with proteomics to identify co‑factors involved in protein amyloid fibril formation.
• Evidence of project leadership, driving direction from hypothesis generation to publication.
• Proactive optimization and troubleshooting of experiments using the latest techniques.

$81,525 - $132,475

• Doctorate degree in a related field and three (3) years of related experience.
• OR Master’s degree in a related field and five (5) years of related experience.
• OR Bachelor’s degree in a related field and seven (7) years of related experience.
• Work experience may NOT substitute for education requirement.

UAB is an Equal Employment/Equal Educational Opportunity Institution dedicated to providing equal opportunities and equal access to all individuals regardless of race, color, religion, ethnic or national origin, sex (including pregnancy), genetic information, age, disability, and veteran's status. As required by Title IX, UAB prohibits sex discrimination in any education program or activity that it operates. Individuals may report concerns or questions to UAB's Assistant Vice President and Senior Title IX Coordinator.

The Title IX notice of nondiscrimination is located /titleix.

University

Scientific Research

Neurology Chair Office

Regular

Shift: Day/1st Shift

Work Arrangement:
Onsite