Postdoctoral Fellow, Chemistry

Overview

The Lewis Lab in the Department of Chemistry at Indiana University is accepting applications for a Postdoctoral Fellow position. The position offers an opportunity to develop and apply cutting‑edge protein engineering techniques to address fundamental challenges in synthetic chemistry and biocatalysis. The successful applicant will use a deep understanding of organic and organometallic chemistry combined with state‑of‑the‑art methods—generative protein design, directed evolution, next‑generation sequencing, and laboratory automation—to develop B12‑dependent enzymes or artificial metalloenzymes containing different organometallic cofactors for new chemical transformations.

Motivated applicants with a PhD in any area of chemistry or biochemistry will be considered. Experience with either molecular biology or synthetic chemistry is strongly preferred.

• Cloning and other molecular biology required for enzyme production and engineering.
• Synthesis of substrates and product standards.
• High‑throughput screening of enzyme libraries.
• Application of computational protein design tools.
• Careful documentation of findings, formal research reports, and presentations.
• Participation in group equipment/facility maintenance.

• PhD in any area of chemistry or biochemistry.
• Extensive experience with either molecular biology or synthetic chemistry.

• Experience with both molecular biology and synthetic chemistry.
• Familiarity with computational design tools, organometallic catalysis/methodology development, enzyme library generation, and screening.

The initial appointment will be for 12 months, with a 12‑month extension available based on performance. A competitive salary and benefits package will be offered.

Submit a cover letter, CV, and contact information for three references to  Applications will be reviewed upon receipt. Best consideration date: 7/21/2026. Expected start date: 10/01/2026.

Questions regarding the position or application process can be directed to Prof. Lewis, Department of Chemistry, Indiana University, 800

E. Kirkwood Avenue, Bloomington, IN 47405, jcl
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For additional information visit: (Use the "Apply for this Job" box below)..

Indiana University is an equal employment and affirmative action employer and a provider of ADA services and prohibits discrimination in hiring. See Indiana University Notice of Non-Discrimination here which includes contact information.