Senior Director, Health Economics and Outcomes Research and Real-World Evidence (HEOR​/RWE

Join Immatics and shape the future of cancer immunotherapy; one patient at a time!

Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME
, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.

• Innovative Environment: Help to pioneer advancements in cancer immunotherapy.
• Collaborative Culture: Be part of a diverse team dedicated to your professional growth.
• Global Impact: Contribute to therapies that make a lasting impact on patients globally.

Immatics is seeking a strategic and highly collaborative Senior Director, Health Economics and Outcomes Research and Real-World Evidence (HEOR/RWE) to establish and lead the company’s global HEOR and RWE capabilities. Reporting to the Vice President, Medical Affairs, this role will be responsible for generating the clinical, economic, patient-centered, and real-world evidence needed to demonstrate the value of these therapies across their development and commercialization life cycles.

The Senior Director will develop evidence strategies that address the distinct clinical and access considerations associated with innovative oncology therapies, including personalized cell therapy. The role provides an exceptional opportunity to shape the value evidence strategy for Immatics’ portfolio as the company progresses late-stage development, launch readiness, and portfolio expansion.

Reports to: Vice President, Medical Affairs

Location: Remote

Salary Range: $260,000 - $295,000

• Advanced scientific / medical degree required (PhD, PharmD, MD, MPH or equivalent).
• 12+ years of biotechnology or pharmaceutical industry experience, including relevant experience in evidence strategy and study execution, HEOR, RWE, market access evidence generation, epidemiology, or outcomes research.

• Advanced scientific / medical degree in health economics, outcomes research, epidemiology, health services research, public health, pharmacy, medicine, biostatistics, or a related discipline
• Demonstrated expertise in oncology HEOR and RWE.
• Knowledge of U.S. payer and formulary decision‑making, integrated delivery networks, oncology care delivery, reimbursement processes, and evidence requirements.
• Experience with cell therapy, gene therapy, other advanced therapy medicinal products, or treatments involving specialized centers and complex patient pathways.
• Experience managing external research collaborations, data vendors, consultants, and contract research organizations.
• Demonstrated record of peer‑reviewed publications, congress presentations, or other high‑impact scientific contributions.
• Ability to communicate complex methodological and technical information clearly to scientific and nontechnical audiences.
• Commitment to scientific integrity, patient‑focused evidence generation, and high ethical and compliance standards.
• Experience supporting interactions with NICE, G‑BA, IQWiG, HAS, ICER, CMS, or other payer and HTA organizations.

• Develop and lead the global HEOR and RWE strategy for Immatics’ portfolio, aligned with clinical development plans, medical strategy, regulatory priorities, market access objectives, and commercialization readiness.
• Develop integrated evidence plans and evidence‑generation roadmaps that identify key research questions, evidence gaps, study priorities, data sources, timelines, and communication plans.
• Establish an HEOR and RWE framework that supports assets from early clinical development through pivotal studies, regulatory review, launch, and post‑launch evidence generation.
• Anticipate evidence requirements across the United States and other priority markets, incorporating payer, reimbursement, HTA, and health‑policy considerations into development plans.
• Develop annual HEOR/RWE objectives, operating plans, resource requirements, and budgets.

• Design and oversee HEOR…