Vice President, Commercial Operations

Who We Are:

Xenon Pharmaceuticals (NASDAQ:

XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy and depression. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. Building upon the positive results and compelling data from our Phase 2b X-TOLE study in adult patients with focal epilepsy, our Phase 3 epilepsy program includes multiple clinical trials evaluating azetukalner in patients with focal onset seizures and primary generalized tonic-clonic seizures.

In November 2025, we announced the completion of patient enrollment in our Phase 3 X-TOLE2 study, and topline data are anticipated in early 2026. We also have multiple Phase 3 azetukalner clinical trials in major depressive disorder (MDD) and bipolar depression (BPD) underway, based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of the leading-edge science coming out of our discovery labs, including early-stage research programs that leverage our extensive ion channel expertise and drug discovery capabilities to identify validated drug targets and develop new product candidates.

We have recently initiated Phase 1 studies for our follow-on Kv7 channel opener, XEN
1120, and our lead Nav
1.7 development candidate, XEN
1701, in pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are looking for a dynamic and strategic Vice President, Commercial Operations to join our Commercial Leadership Team at a critical moment in our company's growth, as we prepare to launch our first commercial product, azetukalner. This role will establish and lead the Commercial Operations function from the ground up - building the infrastructure, systems, team and processes needed for a successful launch and sustained commercial success.

This is an exciting opportunity to shape a function, build a team, and make a direct impact on patients' lives through the successful launch of this transformative therapy.

The Vice President, Commercial Operations will report to the Chief Commercial Officer and lead key areas including sales operations, forecasting, data and analytics, incentive compensation, field effectiveness, market insights, commercial training, and CRM/data infrastructure. This individual will act as a strategic partner to cross-functional leaders across Sales, Marketing, Market Access, Medical Affairs, Finance, IT, and Compliance.

This position will be based out of Boston, MA, USA in our Needham office. We will consider other jurisdictions for exceptional candidates. The level of the position will be commensurate with the candidate's education and industry experience. Relocation and immigration support will be provided, if required. This role is a hybrid position, requiring a minimum of 2 days per week in the office.

RESPONSIBILITIES:

Commercial Strategy & Leadership

• Serve as a core member of the Commercial Leadership Team; develop and execute commercial operations plans aligned with company goals.
• Design and implement a scalable, best-in-class commercial operations model to support pre-launch, launch, and post-launch activities.
• Lead preparation for Quarterly Business Reviews and Board of Directors meetings with strategic performance insights.
• Partner across functions to ensure integrated planning and execution across the commercial landscape.

Sales & Field Operations

• Define and implement field force strategy: structure, sizing, territory alignment, targeting, support, and resource deployment.
• Oversee CRM system implementation and optimization, ensuring strong adoption and utility by field teams.
• Design compliant, motivating incentive compensation plans and ongoing performance tracking.
• Collaborate with Sales Training to support field readiness, onboarding, and capability-building initiatives.

Market Insights, Analytics & Data Management

• Lead development and governance of the commercial data strategy, integrating sales, CRM, claims, and channel, and service program data.
• Build and manage KPIs, dashboards, and reporting tools to drive informed, data-driven decision-making.
• Oversee market research, data analytics, and competitive intelligence efforts to inform commercial strategies and tactics.
• Partner with IT and external vendors to establish and manage a robust Commercial Data Environment (CDE).

Operational Excellence & Budget Management

• Develop and manage Commercial Operations…