Senior Manager/Associate Director, Marketing Operations & Commercial Review
Listed on 2026-07-25
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Business
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Healthcare
Who We Are
Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.
Who We AreXenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.
What We DoWe are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026.
Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial.
In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN
1701 (targeting Nav
1.7) and XEN
1120 (targeting Kv7), which are important pain targets. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.
The Role
Xenon is seeking a Senior Manager/Associate Director, Marketing Operations & Commercial Review to lead the commercial review committee and enable scalable, compliant, and high-quality delivery of programs and tactics. This role will work in close partnership with Marketing, Regulatory, Legal, Medical Affairs, Compliance, and IT to ensure seamless coordination, efficient processes, and strong governance across all marketing activities. This position is critical in a fast-paced, pre-launch environment and requires a highly organized, proactive leader with deep experience in marketing operations, MLR/CRC processes, and cross-functional execution.
This position reports to the Vice President, Commercial Operations, and will be based out of Boston, MA, USA in our Needham office. Hybrid positions require a minimum of two onsite days per week.
- Lead the design, optimization, and execution of the Commercial Review Committee (CRC/MLR) process, ensuring alignment with Marketing, Regulatory, Legal, Medical, and Compliance stakeholders
- Continuously assess and improve CRC workflows, identifying bottlenecks, redundancies, and cycle-time challenges; proactively propose and implement solutions to enhance efficiency and quality
- Serve as primary CRC operations lead, either directly coordinating reviews or managing an outsourced/vendor-supported model depending on capacity and business needs
- Establish and manage CRC governance forums, including coordinating CRC steering committees, setting agendas, and aligning stakeholders on process improvements and priorities
- Lead and coordinate the Executive Review Committee escalation governance committee
- Partner with IT and cross-functional teams to manage systems supporting CRC…
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