Senior Director, Business Operations Lead – Small Molecule, Commercial Manufacturing and Technical Operations

Senior Director, Business Operations Lead

The Senior Director, Business Operations Lead is a senior role within the Business Operations function supporting Commercial Manufacturing and Technical Operations (CMTO). Reporting to the Executive Director, Business Operations and Performance, this role is accountable for product-level business leadership across commercial manufacturing activities, with a primary focus on CDMO business management, manufacturing performance governance, readiness and growth planning, cost of goods oversight, and scenario-based business decision support.

This individual represents the business position for assigned product(s) across governance forums and key cross-functional decision-making bodies. The role ensures that product business requirements are translated into manufacturing priorities, performance expectations, contractual frameworks, and long-range network planning. The Senior Director will work across CMTO and partner functions to support continuity of supply, cost performance, operational readiness, and strategic manufacturing decision-making.

• Serve as the Business Operations lead for assigned product(s) within CMTO, providing product-level business leadership across commercial manufacturing activities.
• Act as the business lead in the CDMO relationship, ensuring business priorities, risks, and requirements are appropriately represented and managed.
• Lead the product-level business position in governance forums related to manufacturing performance against established KPIs.
• Define and communicate business requirements for readiness and growth, and monitor progress to plan, including support for new vendor selection and manufacturing network changes as needed.
• Maintain end-to-end business understanding of CDMO and site performance for assigned product(s), including performance trends, risks, opportunities, and implications to product strategy.
• Establish, monitor, and evolve product-level KPIs with a focus on cost, efficiency, service, and operational performance.
• Develop and maintain performance dashboards and related management reporting to support governance, business reviews, and decision-making.
• Own responsibility for COGM, including establishing cost expectations over time, assessing key cost drivers, and tracking progress against COGM reduction plans.
• Drive product-level business decisions informed by manufacturing performance, including capacity, sourcing, continuity, supply risk, and network considerations.
• Partner with Strategic Sourcing, Manufacturing Operations, Legal, and Finance to develop and implement contract structures that align to the priorities and requirements of supported product(s).
• Lead and support commercial manufacturing scenario planning in support of DST, enterprise, and manufacturing assessments, including scenarios driven by scale, geopolitical changes, supply risk, or evolving business strategy.
• Translate strategic priorities into actionable plans with defined milestones, decision points, accountabilities, and measures of success.
• Identify and escalate business risks, dependencies, and execution gaps, and recommend actions to support timely and effective decision-making.
• Prepare executive-level materials, recommendations, and business updates for leadership reviews, governance discussions, and strategic planning processes.
• Contribute to the ongoing development of business operations processes, tools, and governance frameworks that strengthen execution across CMTO.

• Significant experience in biotechnology, pharmaceutical, or other highly regulated industry.
• Demonstrated experience supporting manufacturing, external manufacturing, CDMO management, or technical operations business processes.
• Experience with product-level business management in a manufacturing environment, including governance, cost oversight, performance monitoring, and cross-functional decision support.
• Proven experience with COGM assessment, tracking, and cost improvement planning.
• Experience leading or contributing to governance forums tied to manufacturing performance, supply strategy, and business risk.
• Demonstrated ability to…