Associate Medical Director, Clinical Development

About Beeline Medicines

Beeline Medicines is a clinical‑stage biotechnology company focused on developing and delivering category‑leading precision therapies to transform the lives of people living with autoimmune and inflammatory diseases. With a portfolio of potential best‑in‑class and first‑in‑disease therapeutic candidates that directly target key pathways governing dysregulated immunological and inflammatory responses, the Company is developing medicines that have the opportunity to provide durable, life‑changing impact.

Led by an established executive team and backed by world‑class life science investors, each day Beeline Medicines is determined to bring the scientific rigor and operational excellence to get to what matters for patients – realizing a world where people with immune‑mediated diseases can live life fully.

The Associate Medical Director, Clinical Development is a therapeutic and disease area specialist who will play a key role in advancing innovative therapies for patients with immunology diseases through high‑quality design and execution of clinical trials. In this role, you will provide medical leadership across a range of clinical development activities, including study design, study execution, monitoring of patient safety, data interpretation, and contribution to regulatory and scientific deliverables.

As an internal scientific leader in the field, you will provide input into the overall clinical development strategy for the asset and incorporate insights from key opinion leader interactions into both study design and development strategy. This role involves working closely with internal cross‑functional partners across a range of disciplines to drive high‑quality clinical programs in a fast‑paced biotech environment.

Hybrid – This position follows a hybrid work schedule, requiring a minimum of two (2) days on‑site per week (currently designated as Tuesday and Wednesday). Additional on‑site days may be required based on business needs, team priorities, or leadership direction.

• Lead and provide medical oversight for assigned clinical trials including protocol development, study conduct, medical monitoring, data review & interpretation, and clinical study reporting.
• Contribute to clinical development strategy and program plans by integrating scientific rationale, regulatory requirements, safety considerations, operational feasibility, and business objectives.
• Provide medical leadership on trial design, including endpoint selection, eligibility criteria, dose rationale, biomarker strategy, risk‑based monitoring, and interim analysis frameworks.
• Monitor real‑time data collection throughout study conduct ensuring robust study conduct and protocol adherence.
• Support pharmacovigilance activities during trial conduct – monitor patient safety and benefit‑risk throughout study conduct through review of adverse events, serious adverse events, laboratory data, safety narratives, aggregate safety information, and contribute to related safety governance activities in coordination with the Global PV Medical Director.
• Serve as a key medical resource for investigative sites, external advisors, and clinical investigators, ensuring patients meet the appropriate eligibility criteria, responding to clinical and safety inquiries and supporting external interactions, advisory boards, and scientific communications as appropriate.
• Lead and conduct peer‑to‑peer scientific exchange with KMEs, investigators, and HCPs – sharing clinical and emerging data, discussing unmet medical needs, and gathering external insights that inform overall development strategy.
• Review, author, and contribute to key clinical and regulatory…