Executive Medical Director

Executive Medical Director, Clinical Development

Rhythm is a global, commercial-stage biopharmaceutical company committed to transforming the lives of patients living with rare neuroendocrine diseases. We develop medicines for previously untreatable or undertreated diseases. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them.

Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.

Rhythm seeks an experienced, strategic, and highly motivated physician to join its Clinical Development team in Boston, Massachusetts. Within the clinical development group, there are multiple ongoing and planned clinical studies of setmelanotide and novel pipeline candidates across rare neuroendocrine and genetic metabolic indications. As an Executive Medical Director, this physician will serve as a senior clinical leader with primary accountability for the design, execution, and oversight of multiple clinical development programs across the development lifecycle (Phase 1–3), providing strategic leadership across one or more disease areas and ensuring alignment of clinical strategy across studies, indications, and lifecycle management opportunities.

The role encompasses end-to-end clinical strategy, protocol architecture, medical monitoring oversight, clinical safety leadership, and clinical ownership of global regulatory submissions and health authority interactions. This high-visibility position will collaborate extensively across executive leadership, cross-functional development teams, and external scientific networks, while serving as a mentor and trusted advisor across the Clinical Development organization and providing guidance to other Medical Directors on study strategy, execution, regulatory interactions, and development best practices.

Responsibilities and Duties

• Program & Study Leadership:
  Serve as the Clinical / Medical Lead across multiple complex clinical studies and development programs, ensuring high-quality trial execution, patient safety, and scientific integrity. Act as a senior clinical development resource within the organization, providing scientific and operational guidance to fellow Medical Directors and study teams.
• Clinical Development Planning & Protocols:
  Lead the creation, optimization, and execution of comprehensive Clinical Development Plans (CDPs) and innovative study protocols for new indications, lifecycle management activities, and future pipeline opportunities.
• Cross-Functional Matrix Leadership:
  Provide strategic medical and scientific leadership across cross-functional matrix teams, including Clinical Operations, Biostatistics, Data Management, Regulatory Affairs, Medical Affairs, Translational Research, and Drug Safety / Pharmacovigilance.
• Medical Monitoring Oversight:
  Provide physician oversight for medical monitoring activities, including subject eligibility evaluation, protocol deviations, endpoint assessment, and emerging clinical issues.
• Safety & Pharmacovigilance Strategy:
  Provide clinical safety leadership across assigned programs, including review of aggregate safety data, SAE evaluation, Benefit-Risk evaluation, and collaboration with Pharmacovigilance to support patient safety.
• Global Regulatory Filings & Defense:
  Lead the clinical authoring, review, and defense of key regulatory documents (including INDs, Briefing Packages, Investigator's Brochures [IBs], Clinical Study Reports [CSRs], and NDA/BLA/MAA clinical modules) and serve as a primary clinical representative in meetings with the FDA, EMA, and other global…