Vertex Fall Co-op, Technical Operations, Process Analytical Technology; PAT

Kickstart Your Career at Vertex!

Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and change lives for the better and for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co‑op, you will work on meaningful projects, collaborate with talented teams, and learn from industry leaders.

We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab.

• Real Projects:
  Work on assignments that make a real impact, not just busy work.
• Mentorship & Networking:
  Connect with leaders and peers who want to see you succeed through professional networks, connections, and collaborations that will shape your long‑term career.
• Flexible & Supportive:
  Offer flexible work options with Flex @ Vertex and prioritize your wellbeing.
• Inclusive Culture:
  Collaboration and inclusion are embedded in everything we do.
• Career Launchpad:
  Build skills, explore career paths, and get guidance for your future career.

The Vertex Technical Operations – Process Analytical Technology (PAT) Co‑Op program is a 6‑month experiential training program for students currently working toward an undergraduate or advanced degree in Chemistry, Analytical Chemistry, Science, Math, Statistics, Engineering, or other related fields. If you are passionate, collaborative, and growth‑minded, a co‑op at Vertex will help you gain meaningful experience in our technical operations functional areas and serve as a launchpad for your career.

Please note that Vertex reviews applications on a rolling basis and reserves the right to close this job posting prior to the listed deadline.

Technical Operations – Process Analytical Technology (PAT) is part of Pharmaceutical Operations and is responsible for process analytical control of Vertex commercial continuous manufacturing processes. This internship allows the candidate to work with a highly diverse group of scientists (i.e., Technical Operations – Process and Automation) to solve complex problems encountered in continuous commercial production/manufacturing of drug products. The intern will have the unique opportunity to explore new horizons to PAT which utilizes material sparing techniques for calibration building – laboratory simulations of manufacturing conditions and universal sample preparations approaches.

This will involve building advanced multivariate models from acquired spectroscopic data of drug product intermediates.

• Design and execute activities and experiments to formulate calibration blends using material sparing techniques and measure them spectroscopically.
• Become proficient in statistical modeling of spectroscopic data. Develop multivariate predictive models (PCA, PLS, etc.) to assess the potency of drug product intermediates.
• Develop new and evaluate existing methods for generating simulated calibration spectra and evaluate their accuracy.
• Support the progress of automated off‑line chemo metric model assessments.
• Report and present results of work to key stakeholders and leadership.

• BS/MS/Ph.D. student majoring in Analytical Chemistry, Chemistry, Science, Math, Statistics, Engineering or related field.
• Basic computer and Microsoft Office skills (e.g., Excel).
• Knowledge of the fundamentals of vibrational spectroscopies (IR, Raman, NIR).
• Demonstrated proficiency in intricate data manipulation using Microsoft Excel.
• Comfort in handling and organizing large datasets.
• Motivated team player and enthusiastic to learn new skills.
• Knowledge of analytical chemistry especially applied to small molecule pharmaceuticals.
• Knowledge of oral solid dosage pharmaceutical manufacturing processes and formulations.
• Experience with multivariate data analysis and model building (PCA, PLS, SIMCA).
• Experience with software tools such as Unscrambler or PLS Toolbox.
• Experience with coding in MATLAB.
• Legal authorization to work in the United States, now and in the future. Vertex does not provide sponsorship for internships or entry‑level roles within this part of the…