Sr. Scientist-LNP Process Development

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism.

We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Verve Therapeutics, a wholly owned subsidiary of Eli Lilly & Company within Lilly Research Labs, is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines.

The company's initial three programs - VERVE-101, VERVE-102, and VERVE-201 - target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. VERVE-101 and VERVE-102 are designed to permanently turn off the PCSK9 gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy.

VERVE-201 is designed to permanently turn off the ANGPTL3 gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia. In 2024, Verve was named a Top Place to Work by The Boston Globe for the fourth consecutive year. Verve is headquartered in Boston, Massachusetts.

We are seeking an experienced LNP Process Development Engineer to join the Late-Stage LNP Process Development team. You will be joining a team that is focused on the development of LNP processes to support late-stage manufacturing readiness activities and drug product process characterization. This lab-facing role will play a critical part in advancing lipid nanoparticle (LNP) process development through characterization of key unit operations, with particular emphasis on high-pressure mixing technologies and tangential flow filtration (TFF).

The ideal candidate will combine technical expertise with collaborative skills to lead and support process characterization studies and work closely with cross-functional teams. The role will also contribute towards Phase 3 process lock and supporting tech transfer and manufacturing readiness activities.

Responsibilities:

* Perform DoE-type studies to support process characterization efforts to identify critical process parameters (CPPs) and characterize appropriate normal operating ranges (NORs) and process acceptable ranges (PARs) for each parameter in each unit operation.

* Collaborate effectively with the process and analytical teams to develop and qualify scale-down models to characterize Phase 3 process.

* Contribute towards locking a scaled-up, Phase 3-ready process through execution of on-going de-risking studies.

* Support technology transfers of late-stage programs to manufacturing sites and contribute towards batch readiness activities and technical investigations as required.

* Author relevant process development and characterization reports and provide support as required in authoring regulatory documents.

* Participate actively in technical discussions and meetings, proactively communicate technical findings and results to stakeholders.

* Ensure lab notebooks are kept updated and support equipment troubleshooting and maintenance as needed.

Basic

Qualifications/Requirements:

* BS Degree in a relevant scientific discipline (Chemical Engineering, Biomedical Engineering, Biotechnology, or related field with 3+ years of industry experience with LNP formulation.

OR

* MS Degree in a relevant scientific discipline (Chemical Engineering,…