Global Accounts Payable Manager

Company Overview

Rhythm is a biopharmaceutical company aimed at developing and commercializing therapies for the treatment of rare genetic diseases of obesity. Working at Rhythm means that you are part of a team that is passionate about transforming the lives of people living with rare genetic diseases of obesity. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need.

Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.

Rhythm Pharmaceuticals is seeking a Global Accounts Payable Manager to join our Finance and Accounting team. The Global Accounts Payable Manager is responsible for leading and optimizing the end‑to‑end accounts payable function across multiple regions and legal entities. This role ensures timely, accurate, and compliant processing of vendor payments for both the US and international entities, while driving standardization, automation, and continuous improvement across global AP operations.

Reporting to the Senior Director, Accounting & Financial Reporting, this role is a critical member of the accounting operations team, with interaction with the Corporate Controller, International Controller and many other operational stakeholders.

• Lead and manage global accounts payable operations across multiple countries, currencies, and entities
• Oversee vendor management, invoice processing and employee reimbursements
• Ownership of global payment runs and AP mailbox
• Lead the travel and expense reimbursement function, including policy oversight, system administration and optimization of Concur functionality.
• Ensure compliance with internal controls, SOX requirements, local statutory regulations, and company policies
• Drive standardization of AP processes and controls across regions while balancing local regulatory needs
• Manage and develop regional AP teams, including performance management, training, and career development
• Serve as the primary escalation point for complex vendor issues, payment discrepancies, and audit inquiries
• Partner with Procurement and business stakeholders to improve purchase‑to‑pay (P2P) efficiency and vendor experience
• Own AP‑related month‑end and year‑end close activities, including accruals, reconciliations, and reporting
• Lead AP participation in internal and external audits; ensure timely remediation of findings
• Drive automation and process improvement initiatives (e.g., invoice capture, workflow tools, ERP enhancements)
• Monitor and report on key performance indicators (KPIs) such as invoice cycle time, payment accuracy, invoices processed, and aging
• Support global ERP implementations, system upgrades, and integrations related to AP processes
• Perform other responsibilities across the accounting department as needed.

• Bachelor’s degree in accounting or finance preferred
• 5+ years of progressive experience in a public-company accounts payable group;
  Biotech/Pharmaceutical preferred
• 2+ years of people management experience, preferably managing geographically dispersed teams
• Ability to drive continuous improvement to optimize processes and maintain a solution-oriented mindset
• Ability to work both independently and deliver on responsibilities within a highly collaborative environment
• Excellent attention to detail, project management and organizational skills
• Strong knowledge of AP processes, internal controls, and SOX compliance
• Demonstrated ability to lead process transformation and operational scalability
• Strong analytical, problem‑solving, and organizational skills
• Excellent communication and stakeholder management skills
• Ability to operate effectively in a fast‑paced, global environment across time zones
• Proficiency in Excel
• Experience working with ERP systems (Microsoft D365, Oracle Fusion, Net Suite, etc) and AP/P2P automation tools (i.e. Coupa) is preferred

This role is based out of our corporate office in Boston, Massachusetts. Rhythm operates…