Post-doctoral fellow

Michael Farzan’s laboratory at Boston Children’s Hospital and Harvard Medical School engineers lymphocytes – B cells and T cells – for a range of scientific and translational goals. For example, this technology allows us to use murine germinal centers to select potent and highly bioavailable human antibodies. It also provides us useful animal models to evaluate and improve vaccines, as well as a new way to address unanswered questions in lymphocyte-cell biology and adaptive immunity.

Finally, the chimeric antigen receptor (CAR) B cells and CD4-positive CAR T cells so generated can themselves be conceived of as a therapy for many disease states including HIV infection.

Because our engineered B cells affinity mature, we apply them to our efforts to predict uniquely human responses to candidate vaccines in mice and non-human primates. This tool is critical for our parallel efforts to develop novel antigens that elicit antibodies in humans that protect from HIV-1 infection. Finally, we seek to develop better genome editing and gene delivery tools that will improve the quality and safety of our engineered lymphocytes.

The payrange is Boston Children Hospitals’s reasonable and good-faith expectation for thispayat the time of posting, and depends on skills, experience, education, certifications, and a variety of other job-related factors. BCH offers a comprehensive benefits package that includes flexible schedules, medical/vision/dental coverage, child-care and student-loan subsidies, generous paid time off, a 403(b) retirement plan, commuter and other employee discounts. Boston Children’s Hospital requires influenza vaccination for all employees, unless eligible for a medical or religious exemption.

Boston Children’s Hospital is an Equal Opportunity/Affirmative Action Employer; all qualified applicants will receive consideration without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status, disability, or other protected status.

This is a full-time on-site position for a Post-doctoral Fellow at Boston Children's Hospital in Boston, MA. The Fellow will engage in advanced research activities, perform laboratory experiments, analyze data, contribute research publications, academic teaching and mentoring, and work closely with other members of the laboratory to advance new science that contributes to human health.

• A Ph.D. in biological science, bioengineering, or a related field.
• Proficiency in cell culture and molecular biology techniques.
• An ability to work effectively with others.
• A willingness and ability to learn new science and technologies.
• A commitment to training students, research assistants, and other fellows.
• Previous experience in vivarium studies, bioinformatics and/or immunology would be a plus.