Vice President, Clinical Development

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Tango Therapeutics is seeking an experienced oncologist to serve as Vice President Clinical Development for our PRMT5 programs in development for MTAP‑deleted cancers. This strategic leadership role will drive clinical development strategy and execution as we advance into Phase 3 development. You will serve as the clinical and scientific voice for the program. This role reports directly to the SVP, Head of Clinical Development and plays a critical part in advancing Tango's precision oncology pipeline.

In this role, you will drive our pivotal phase III programs for TNG
462 by leading protocol development, amendments, and operational execution, while partnering with the Head of Clinical Development on strategy and key decisions. You will work cross‑functionally with Clinical Operations, Regulatory, Medical Affairs, Biostatistics, and others; partner with Medical Affairs on publications, abstracts, and investigator meetings; represent Clinical Development in industry partnerships; and design and initiate study protocols and amendments in compliance with GCP/ICH and regulatory requirements.

• Directly manage clinical scientists supporting the PRMT5 program
• Provide mentorship and development opportunities for emerging clinical leaders
• Foster a culture of scientific rigor, operational excellence, and collaboration

• Provide strategic input into regulatory meeting planning, preparation, and slide deck development
• Lead authorship and provide close oversight of regulatory documents including protocols, INDs, briefing documents, and responses to health authority questions
• Support the development and compilation of regulatory filings including INDs, CTAs, and NDAs

• Partner with Project Management on clinical governance meeting agendas and cross‑functional alignment
• Establish and drive operational improvement initiatives
• Work closely with clinical teams to support patient recruitment strategies and maintain strong relationships with Principal Investigators
• Monitor adherence to protocols and ensure consistency in quality standards across all program activities

• Build and maintain relationships with key investigators, thought leaders, and clinical trial sites
• Act as liaison between company and clinical investigators
• Represent PRMT5 clinical development at scientific conferences and investigator meetings
• Review/co‑author medical publications emerging from clinical trial results

• MD degree with board certification or eligibility in medical oncology or hematology‑oncology
• Minimum 15+ years of clinical development experience in oncology in the biotechnology or pharmaceutical industry, with at least 5 years in late‑stage (Phase 2/3) programs
• Hands‑on experience in the design, execution, and reporting of clinical trials in oncology, evaluating small molecule targeted agents and/or immunological therapies
• Direct experience with IND filings required
• Demonstrated experience leading global clinical programs from protocol design through regulatory submission
• Strong scientific writing skills with proven track record of regulatory document authorship
• Experience managing and mentoring clinical development teams
• Deep understanding of ICH‑GCP, FDA regulations, and global regulatory requirements
• Effective leadership, people management, team‑oriented and results‑oriented style with strong interpersonal,…