Director, Clinical Science

Olema Oncology is a clinical-stage biopharmaceutical company committed to transforming the standard of care and improving outcomes for patients living with breast cancer and beyond. It’s an exciting time to be part of Team Olema , with our transfor mation into a fully integrated oncology company well underway , t op-line data from our lead program expected later this year , and our first potential commercial launch on the horizon.

Our leadproduct candidate, palazestrant, isa novel, orallyavailablecomplete estrogen receptor antagonist (CERAN) and selective estrogen receptor degrader (SERD) currently intwopivotal

Phase 3clinicaltrials. We expect top-line data from OPERA-01,our ongoing

Phase 3 trial of palazestrantas a monotherapy in patients withsecond- or third-lineER+/HER2-metastatic breast cancer (MBC), in the fall which, if successful, could lead to our first potential approval and commercial launchin 2027. OPERA-02,our Phase 3 trial of palazestrantin combination with ribociblibin patients with frontlineER+/HER2- MBC, isenrolling patients. Togetherwith its mechanism of action, pharmacokinetic properties,andthe potential todemonstrateactivity in both ESR1wild-type and mutant tumors, palazestranthas the potential to transform the metastatic breast cancer treatment paradigm andaccess a $15 billionglobal market opportunity.

Aspiring to transform the metastatic treatment paradigm is an ambitious endeavor that requires a resolute approach to developing better therapies and a passionate team dedicated to helping the patients we serve feel better, longer. We possess a deep commitment to our shared purpose, the sustained pursuit of excellence, cultivating the courage required to advance our programs, drive to succeed, and a collective capacity for adaptability through learning, growth, and evolution.

Team Olema is made up of nimble self-starters who bring consistency in their quest for the extraordinary every single day.

If you’re ready to be part of a tenacious, courageous, agile, and growing team, join us in making a profound impact, together – for our patients, for your career, and for what’s beyond.

As the Director, Clinical Science reporting to the Vice President, Clinical Science, you will play a key role in one of our ongoing clinical studies. You will work collaboratively in a multi-disciplinary team setting including Clinical Operations, Medical Monitors, Data Management, Biostatistics, Clinical Pharmacology, Regulatory and Program Management, in the planning, conduct and analysis of clinical trials.

Your job contributes to and supports Olema’s mission of developing therapies that offer the potential to improve outcomes for women living with cancer.

This role is based out of our San Francisco, CA or Cambridge, MA office and will require up to 20% travel.

Your work will primarily encompass:

• Writing of technical and clinical documents including protocols, amendments, investigator’s brochures, and the clinical sections of regulatory documents
• Working with the study team to identify and track any potential safety events within a given trial
• Interacting with investigators and thought leaders in oncology to facilitate the design of clinical synopses and protocols
• Evaluate the safety, pharmacology, and efficacy of ongoing studies in close collaboration with the medical monitor and the safety, pharmacology and clinical operations teams
• Organizing and performing the study level and individual subject level analysis of the clinical trial data to gain insights and develop strategies for the clinical study report (CSR) writing
• Contributing to the writing and/or review product specific abstracts, publications and supporting the development of presentations for scientific meetings
• Maintaining clinical and technical expertise in the therapeutic area of oncology
• Attending scientific meetings pertinent to clinical science activities

And will also include:

• Collaborating with the Medical Monitor on review of enrollment packets, clinical development plans and scientific presentations
• Collaborating with Clinical Operations and other internal study teams to develop Informed Consent…