Nuclear Pharmacist

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The General Hospital Corporation

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Under direction of the Senior Operations Manager, PET Production and Cyclotron, the nuclear pharmacist provides a variety of services, ensuring compliance in the procurement, preparation, compounding, manufacturing, quality control testing, dispensing, distribution, and monitoring of radiopharmaceuticals. The nuclear pharmacist also must provide support for the safe and efficient production and use of radioactive drugs for research and clinical diagnostic use  incumbent is involved in all aspects of the day-to-day operation of the PET Production and Nuclear Pharmacy radiopharmaceutical facilities.

In addition, the nuclear pharmacist provides consultation regarding all aspects of the use of radiopharmaceuticals and non-radioactive adjunct imaging medications, as well as health and safety issues in patient care.

• 1.Assumes overall responsibility for quality oversight of the FDA regulated, cGMP PET manufacturing facility and PET nuclear pharmacy for the manufacturing, compounding, quality control testing, dispensing and packaging of PET radiopharmaceuticals.
• 2.Serves in a quality assurance (QA) role to ensure compliance with all departmental procedures, FDA guidance and regulatory filings.
• 3.Reviews and releases batches of PET radiopharmaceuticals manufactured under 21 CFR 212, cGMP PET drug manufacturing regulations.
• 4.Ensures compliance with all state, federal, and local regulations concerning these activities.
• 5.Maintains inventory and ensures suitability of all raw materials and components used in the production of PET radiopharmaceuticals
• 6.Performs set up, operation, and documentation of computer controlled automated synthetic devices dedicated to the production of PET radiopharmaceuticals.
• 7.Performs complex analytical testing on manufactured and/or compounded radiopharmaceutical including, thin layer chromatography (TLC), high performance liquid chromatography (HPLC), gas chromatography (GC), radionuclide identity and purity testing with high purity germanium solid state detectors, sterility and pyrogen testing.
• 8.Works with PET radiochemistry staff to troubleshoot radiopharmaceutical production and optimize yields.
• 9.Works with cyclotron facility staff to ensure quality and availability of PET radionuclides for manufacturing and compounding of PET radiopharmaceuticals.
• 10.Maintains detailed records of operation and validation of all processes taking place in the nuclear pharmacy and PET production facility.
• 11.Ensures that all shipments of radioactive material meet all regulatory requirements.
• 12.Works with MGH radiation safety staff to ensure that all tasks are performed in the PET nuclear pharmacy are in compliance with regulatory and prudent radiation safety principles.

• 1.Responsible for the safe and effective preparation and dispensing of diagnostic and therapeutic radiopharmaceuticals for Nuclear Medicine, Nuclear Cardiology, Thyroid Associates, and Interventional Radiology.
• 2.Responsible for procurement, receiving, inventory control, storage, handling, preparation, compounding, quality control testing, and disposal of radiopharmaceuticals and adjunct imaging medications.
• 3.Responsible for Medication Order Review - allergy monitoring, drug interaction monitoring, adverse reaction monitoring and reporting.
• 4.Maintains appropriate records for regulatory compliance.
• 5.Prepares and dispenses radiopharmaceuticals according to departmental protocols and patient specific information
• 6.Provides drug information such as potential drug interactions and methods of radio-labeling to the nuclear medicine department.
• 7.Prepares and dispenses medications for departmental clinical trials and completes applicable case report forms.
• 8.Maintains quality standards to ensure compliance with Massachusetts Radiation Control Board regulations, Board of Registration in Pharmacy, United States Pharmacopeia, and The Joint Commission.
• 9.Ensures therapeutic radiopharmaceuticals are dispensed in accordance with the departmental quality management program.
• 10.Participates in the vendor assessment process
• 11.Supervises nuclear medicine technologists in the preparation and dispensing of radiopharmaceuticals
• 12.Provides training on aseptic technique, radiopharmaceutical preparation and quality control, and radiation safety…