Analytics CoE Senior Manager

Key Responsibilities:

• Leverage Vertex's in-licensed RWE data assets to conduct queries and analyses supporting the Vertex product portfolio and development programs across therapeutic and disease areas.
• Conduct feasibility assessments to inform design/execution of research projects.
• Conduct health economic and outcomes research to characterize disease burden, healthcare resource utilization, co-morbidities, and treatment patterns in real-world populations.
• Generate actionable insights to address key business questions from internal and external stakeholders.
• Lead development of study protocols, statistical analysis plans, and table shells.
• Support statistical programmers by executing data queries and analyses.
• Generate analytic reports, tables, and visualizations to communicate findings to internal stakeholders.
• Collaborate with cross-functional colleagues to improve the analytics operating model.
• Develop/enhance/maintain internal analytic tools (e.g., programming libraries, reusable macros, table templates).
• Support HEOR disease/asset leads in assessing research gaps and evidence generation objectives.

• Advanced degree in health economics or related discipline (math, statistics, economics, epidemiology).
• Typically 6 years of relevant experience in health economics and outcomes research (or equivalent: Doctorate + 2 years; Master’s + 4 years).
• Knowledge of observational research methods for studies of disease burden, resource utilization, treatment patterns, comorbidities, and outcomes.
• Hands-on experience analyzing large patient-level healthcare datasets (open/closed claims, EHR/EMR, hospital charge master; e.g., Market Scan, Phar Metrics Plus, eLAAD+, Premier).
• Working knowledge of national healthcare coding systems (diagnostic, procedure, drug) and healthcare system structures.
• Advanced proficiency in SAS programming and Excel required.
• Excellent written and oral communication skills.
• Ability to plan, organize, and manage multiple projects across therapeutic areas.