ADME Project Leadership Genetic Medicines

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve.

This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Our ADME team is seeking a scientist with an interest in the discovery and clinical development of genetic medicines, including gene editing, gene therapy, siRNAs, ASOs, and other emerging modalities. We develop transformative therapeutics that address the underlying causes of disease across a wide range of therapeutic areas. We welcome applicants with strong problem-solving skills and innovative thinking to join our growing Boston campus team.

Lilly's ADME team collaborates with biologists, chemists, engineers, and other R&D functions across all stages of discovery and development, sharing learning and responsibility for advancing next-generation genetic therapies. We foster professional growth and welcome motivated, collaborative scientists who want to help improve patient outcomes globally.

• High learning agility and the ability to articulate and efficiently test ADME and PK/PD hypotheses for complex novel molecules
• Strong working knowledge in fundamental pharmaceutics, pharmacokinetics/pharmacodynamics, and ADME principles - especially as they relate to genetic medicine therapeutic modalities
• Ability to interrogate diverse data (e.g., in silico, in vitro, in vivo) to derive mechanistic understanding of drug action and ADME/DMPK characteristics
• Understanding of pharmaceutical regulatory guidance and expectations

• Lead and innovate in a multidisciplinary team environment with primary responsibility for ADME studies to support preclinical and clinical development of the Lilly genetic medicines portfolio
• Integrate ADME, PK and PK/PD endpoints with discovery chemistry and biology data to guide preclinical drug design, optimization, and delivery strategies.
• Design, implement, and interpret hypothesis-driven studies to inform key ADME, PK/PD, and toxicokinetic (TK) questions
• Collaborate and innovate with cross-functional and interdisciplinary colleagues
• Lead the preparation of ADME portions of regulatory communications and documents to support clinical development, new drug applications, and line extensions and interact with global regulatory authorities
• Mentor and build relationships with colleagues at all levels through coaching and support
  
  Strong written and verbal communication skills, with the ability to constructively lead and influence teams

Ph.D. in Biochemistry/Biology/Pharmacokinetics/Bioengineering/Pharmacology or a related scientific field

Greater than five years of experience as a scientist in a pharmaceutical and/or biotechnology company in a role related to ADME or PK/PD

• Knowledge of DMPK and/or bioanalytical considerations for gene editing and/or gene therapy modalities
• Experience with PK/PD modeling and simulation
• Experience with targeted delivery and biodistribution of oligonucleotides and/or gene therapies
• Understanding of and experience with PCR, immunoassay, and/or LC/MS bioanalytical methodology

This is a full-time position located in Boston, MA.

Lilly is dedicated to helping…