Principal Scientist, Pharmacokinetics

## Principal Scientist, Pharmacokinetics Apply:
Not Applicable:
USA
- Massachusetts
- Boston (MA Parcel B Laboratory):
Full time:
Posted Today:
End Date:
October 16, 2026 (23 days left to apply):
R418498
** Job Description
**** Boston Pharmacokinetics, Dynamics, Metabolism and Bioanalytics – Principal Scientist
** Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where our company has codified its legacy for over a century. Our company’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.  

At our company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating an organization that is inspired by invention and founded on a culture of respect and collaboration.

At our Research & Development Division, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.  The Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking a dynamic, strategic thinking and collaborative Principal Scientist (director-level equivalent) to contribute to our company’s drug discovery and early clinical development efforts. This position will be based at our research labs in Boston, MA.

The ideal candidate will lead drug metabolism and pharmacokinetic (DMPK) efforts across multiple modalities (small molecules, peptides, protein therapeutics) as a project-team representative, regularly interacting with multi-disciplinary discovery teams and partners from other functions within our Research & Development Division. Therapeutic area support with focus on our immunology and oncology portfolios, with the potential to contribute to cardiovascular/metabolic, neuroscience and infectious disease efforts as well.  

The successful candidate will be expected to represent PDMB on cross-functional teams through strategic design of discovery testing funnels, generation and interpretation of PK and PK/PD data sets and through effective communication at both internal meetings and external conferences.  
** In this exciting position, your primary roles will include:*
* * Project-team representative and subject matter expert on multiple modality DMPK activities within the oncology and immunology therapeutic areas
* Characterization and optimization of the in vitro and in vivo ADME and pharmacokinetic properties of small molecules and peptide therapeutics
* Design, implementation and analysis of in vitro and in vivo studies to understand the impact of drug disposition on disease biology, pharmacological response (PK/PD) and safety
* Manage a team of lab-based PDMB scientists responsible for developing and executing ligand binding assays and mass spectrometry-based bioanalytical strategies
* Contribute to global DMPK strategy and implementation of cutting-edge ADME science through close collaboration with Discovery and Early Development project teams in Boston (MA), South San Francisco (CA) and West Point (PA) focusing on building highly efficient strategies to identify and optimize drug candidates  
** Education Minimum Requirement
*** Ph.D (with 6+ years relevant experience) or Master’s (minimum of 10 years relevant experience)…