Director​/Senior Director, Human Resources, Commercial

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026.

Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial.

In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN
1701 and XEN
1720 (targeting Nav
1.7) and XEN
1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

The Director/Senior Director, Human Resources, Commercial, serves as the primary HR Business Partner to the SVP, Sales & Marketing and the Sales & Marketing Leadership Team. This role is responsible for translating Commercial business priorities into people, talent, organizational, and workforce strategies that support commercialization objectives and long-term business growth. As a key member of the Commercial HR team, this role leads the continued build-out and evolution of Xenon's Sales and Marketing organizations.

The role advises leaders on organizational structure, workforce planning, leadership capability, talent strategies, and organizational readiness while ensuring the organization has the capabilities, talent, and workforce plans required to support successful commercialization. This critical role also serves as the HR Lead for Xenon's Launch Readiness Core Team, representing HR in cross-functional launch planning activities and ensuring alignment between Commercial priorities and HR deliverables.

This role acts as the primary connection between the Launch Readiness Core Team and the broader HR organization, ensuring HR activities are executed in support of commercialization readiness while providing organizational insights, workforce considerations, and people-related recommendations to support decision-making. The successful candidate will bring strong business acumen, HR Business Partner experience, and a demonstrated ability to influence leaders, lead complex initiatives, and drive execution in a fast-paced and evolving environment.

This position reports to the Vice President, Human Resources, Commercial, and will be based out of Boston, MA, USA in our Needham…