Senior Clinical Scientist

Senior Manager/Associate Director, Clinical Scientist About Us

Damora Therapeutics is an innovative biotechnology company that aims to fundamentally redefine care for people with hematologic disorders. We are advancing a new generation of biologics to treat mutant calreticulin-driven myeloproliferative neoplasms, including essential thrombocythemia and myelofibrosis, where there is significant medical need for new disease-modifying treatments. With multiple programs with best-in-class potential on track to enter clinical development in 2026, our goal is to rapidly bring forward optimized treatments with broad mutation coverage and exceptional convenience to dramatically improve patient outcomes.

This is a unique opportunity to join a science-driven company at a formative stage, where early clinical data will directly shape development strategy and drive long-term value. The right candidate will join a team with significant early- and late-stage development experience, with the goal of quickly moving through dose escalation/expansion into pivotal trials.

We are seeking a Senior Clinical Scientist to play a critical, hands‑on role in the design, execution, and analysis of our first‑in‑human clinical trials. This individual will serve as a key scientific partner to Clinical Development, Clinical Operations, Translational Science, Regulatory, Biometrics, and Safety, with a leadership role in study‑level strategy and execution.

The Senior Clinical Scientist will contribute meaningfully to the authorship and review of essential study documents; clinical data oversight (including data cleaning, review, analysis, and interpretation); regulatory submissions and responses; and clinical site training and engagement, while also helping establish best practices as the clinical team scales.

This role reports to the Vice President of Clinical Development.

• Serve as Clinical Scientist on one or more Phase 1 first‑in‑human dose escalation trials in hematologic malignancies.
• Contribute to the clinical development plan for a pipeline of mCALR targeting antibodies.
• Co‑author and review key clinical documents, including protocols, amendments, IBs, and cross‑functional documents like eCRFs and completion guidelines, SAP TLF shells, and regulatory briefing books.
• Support dose‑escalation decisions through real‑time review and visualization of emerging safety, PK/PD, and biomarker data.

• Act as a core member of cross‑functional program teams, partnering closely with Clinical Operations, Translational Medicine, Regulatory, Biometrics, and Safety.
• Collaborate with Translational and Preclinical teams to integrate biomarker and mechanistic hypotheses into clinical studies.
• Provide scientific input into data review meetings, SRCs, and internal governance forums.

• Perform ongoing review and interpretation of clinical data, including safety, efficacy, PK/PD, and exploratory biomarkers.
• Contribute to internal data summaries, regulatory responses, and external communications.
• Support preparation of abstracts, posters, and manuscripts for scientific meetings and publications.

• Support interactions with investigators, CROs, and vendors to ensure high‑quality trial execution.
• Participate in investigator meetings and scientific training sessions.
• Assist in regulatory interactions by preparing clinical science content for INDs, amendments, and agency questions.

• PhD, Pharm
  
  D, or equivalent advanced scientific degree required.
• 5+ years of experience in clinical research or clinical development, with industry experience strongly preferred.
• Solid understanding of clinical trial design, clinical data analysis, and drug development principles; direct experience supporting early‑phase (Phase 1 / FIH) clinical trials is preferred.
• Experience in hematology or oncology preferred (MPN experience a plus).
• Ability to work effectively in a fast‑paced, highly collaborative biotech environment.
• Excellent written and verbal communication skills, with demonstrated experience contributing to regulatory and scientific documents.

At Damora Therapeutics, we offer competitive compensation and thoughtfully designed total rewards aligned with industry benchmarks. We believe in rewarding impact and building meaningful ownership for our team.

We are building our team intentionally and do not accept unsolicited resumes from recruiting or staffing agencies. Agencies should not submit candidates unless directly engaged by Damora’s HR team and operating under a signed agreement. Any resume submitted without prior authorization and a signed agreement will be considered property of Damora Therapeutics, and no referral or placement fees will be paid.