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Principal Analyst, CGT Agentic Solutions

Job in Boston, Suffolk County, Massachusetts, 02298, USA
Listing for: Vertex Pharmaceuticals
Full Time position
Listed on 2026-06-25
Job specializations:
  • IT/Tech
    AI Engineer (Applied/Software), Data Engineering
Salary/Wage Range or Industry Benchmark: 142800 - 214200 USD Yearly USD 142800.00 214200.00 YEAR
Job Description & How to Apply Below
## Principal Analyst, CGT Agentic Solutions Apply locations:
Boston, MAtime type:
Full time posted on:
Posted Todayjob requisition :
REQ-29200
** Job Description
**** General Summary
** Vertex is seeking a Principal Analyst, CGT Agentic Solutions to drive the design and implementation of advanced AI-enabled and agentic technologies across our Cell and Gene Therapy (CGT) organization. This role is ideal for a technically strong professional who can bridge data, AI, systems integration, and digital product delivery to create scalable solutions in a complex and highly regulated environment.

The Principal Analyst will work closely with engineering, data, platform, and business analysts to develop intelligent solutions that automate workflows, orchestrate information, enhance decision-making, and improve operational efficiency across CGT. This role will play a key part in shaping how agentic architectures, AI services, and enterprise data ecosystems are applied to real-world scientific and operational challenges.
** Key

Duties and Responsibilities:

*** Design and support the implementation of agentic and AI-enabled solutions for CGT use cases across commercial, development, manufacturing, quality, and supply chain
* Translate technical and operational needs into solution designs, system requirements, integration patterns, and implementation plans
* Partner with software engineers, data engineers, architects, and product teams to deliver scalable and secure digital solutions
* Define and evaluate agent workflows, orchestration logic, prompt patterns, tool usage, and knowledge retrieval approaches for enterprise applications
* Support development of solutions leveraging large language models, retrieval-augmented generation, workflow automation, APIs, and enterprise data services
* Analyze existing systems, data flows, and technical architectures to identify opportunities for automation, optimization, and modernization
* Contribute to the design of data pipelines, integration frameworks, and system interoperability models supporting agentic platforms
* Ensure solutions align with security, privacy, validation, and compliance requirements in a regulated biotechnology environment
* Establish technical standards, performance measures, and operational monitoring approaches for deployed solutions
* Evaluate emerging AI, cloud, and automation technologies and recommend practical applications within CGT
* Support production readiness, testing strategy, release planning, and continuous improvement of technical solutions
* Serve as a technical leader and subject matter expert for agentic solution capabilities within the CGT digital ecosystem
** Knowledge and

Skills:

*** Hands-on experience working with AI/ML-enabled applications, enterprise platforms, system integrations, or intelligent automation solutions
* Experience defining and supporting the implementation of technical architectures, APIs, data flows, and workflow automation patterns
* Strong understanding of large language models, agentic systems, orchestration concepts, or applied AI solution design
* Experience collaborating with engineering, architecture, data, and product teams in Agile or product-based delivery environments
* Strong analytical and technical problem-solving skills with the ability to work across complex enterprise ecosystems
* Familiarity with compliance, security, data governance, and validation considerations in regulated environments
** Technical

Skills Required:

*** Large language model application design and AI solution analysis
* Agentic workflows, orchestration frameworks, and prompt design concepts
* API design/integration and service-based architecture
* Data modeling, data flows, and enterprise integration patterns
* Workflow automation and intelligent process orchestration
* SQL and data analysis skills
* Experience with scripting or programming languages such as Python, SQL, or similar
* Familiarity with cloud platforms and modern data ecosystems
* Understanding of RAG architectures, vector search, knowledge retrieval, and document grounding approaches
* Experience with tools and platforms such as Azure, Databricks, Power BI, Jira, Confluence, Git, or similar…
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