Director​/Senior Director, Supply Chain

About Xenon Pharmaceuticals

Xenon Pharmaceuticals (NASDAQ:

XENE) is a neuroscience‑focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life‑changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression, and pain. Our Phase 3 azetukalner program is the most advanced, clinically validated potassium channel modulator in late‑stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X‑TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026.

Our Phase 3 epilepsy program also includes a second FOS study, X‑TOLE3, which would support regulatory submissions outside the U.S., and the X‑ACKT study in primary generalized tonic‑clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X‑NOVA clinical trial.

In 2025, we initiated Phase 1 trials for XEN
1701 (targeting Nav
1.7) and XEN
1120 (targeting Kv7). Nav
1.7 and Kv7 are important pain targets, and data from these Phase 1 studies are expected in 2026 to support Phase 2 proof‑of‑concept studies in acute pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

This role reports to the Executive Director, Supply Chain and will be based out of Boston, MA, USA in our Needham office. We may consider remote locations for exceptional candidates. Hybrid positions require a minimum of two onsite days per week.

The ideal candidate will be a strategic partner working with cross‑functional leaders to support this critical next step for Xenon, balancing speed with accuracy, applying critical thinking, and ensuring integrated planning, capacity management, systems, and governance as programs advance toward commercialization. The leader will be both strategic and hands‑on, capable of setting direction while driving execution across multiple programs and external partners.

• Lead and manage end‑to‑end supply chain strategy and execution across clinical, pre‑commercial, and commercial phases, including launch and post‑launch stabilization. Design and implement scalable supply chain models that evolve with program maturity, from early clinical supply through first commercial launches and lifecycle expansion.
• Lead integrated demand, supply, and inventory planning across clinical and commercial horizons, ensuring alignment with development milestones, launch timing, and evolving demand forecasts.
• Establish and mature S&OP or equivalent integrated planning forums, enabling clear visibility to trade‑offs, constraints, and executive decision points.
• Lead scenario planning to evaluate alternative demand and supply assumptions and inform capacity decisions and risk‑mitigation strategies.
• Lead supply chain readiness for key commercialization milestones, including late‑stage clinical supply continuity, transition planning, commercial supply chain design, distribution model definition, commercial lot readiness and launch inventory build.
• Ensure supply chain deliverables are aligned with regulatory submissions, labeling, serialization, and market launch requirements.
• Support launch execution and early commercial stabilization, including issue resolution, performance tracking, and continuous improvement.
• Manage relationships with third‑party manufacturers, suppliers, and vendors to ensure timely delivery of materials, components, and finished goods.
• Negotiate and manage performance…