Commercial Supply Chain Manager, Molecule

Job Description General Summary

The Commercial Supply Chain Manager will support commercial supply chain execution for a late‑stage small molecule program. As Vertex expands its portfolio and advances new therapies toward commercialization, this role will play a key part in monthly supply planning, the S&OP process, planning system setup, inventory management, Long Range Plans (LRP) and cross‑functional supply‑chain coordination.

The position is responsible for delivering the monthly supply planning tasks, support in the S&OP process, setting up planning & execution systems and partnering with cross‑functional teams to align material, capacity and operational requirements to support on‑time manufacturing execution and product supply. The role will also support process integration, system testing and continuous improvement efforts to help build a best‑in‑class supply chain.

This position reports to the Associate Director, Commercial Supply Chain - Pipeline, within Supply Chain Management and the Biopharmaceutical Sciences and Manufacturing Operations (BSMO) division, and is based at Vertex's corporate headquarters in Boston, MA.

• Deliver monthly end‑to‑end supply and inventory build plans using Kinaxis Maestro / Rapid Response, taking into consideration supplier capacity, demand uncertainty and overall risk management.
• Support the commercial and late‑stage small‑molecule program including scenario planning to facilitate data‑driven decisions. The scenario planning includes supply projections, 5+ year forward‑looking assessments of forecast / supply scenarios and inventory planning to support life‑cycle management initiatives.
• Support implementation, testing and improvement of planning and execution systems functionality to further advance technology and planning processes optimization / efficiency. Serve as planning super‑user for Kinaxis Maestro / Rapid Response.
• Support the Sales & Operations Planning (S&OP) process to enable robust material and capacity investments including network expansion. Proactively assess risks across the small‑molecule network and develop mitigation plans.
• Support supply‑chain strategic initiatives such as implementing safety stock for materials, monitoring operational readiness, capacity analysis and integration of different systems requirements.
• Lead creation and maintenance of master data, including lead times, pricing and approved vendor lists and perform periodic review of master data and ensure alignment with department policies and guidelines.
• Drive excellence in end‑to‑end operations through management of key supply‑chain KPI’s. Identify operational efficiency and continuous improvement opportunities across the supply chain to deliver a best‑in‑class supply chain.
• Represent the supply chain on project sub‑teams and task forces, executing supply‑chain production activities with general guidance, building strong relationships with external manufacturing, quality, logistics, finance, commercial and other functions, fostering team culture and building trust with colleagues to deliver uninterrupted supplies to patients.
• Champion the culture of quality and ensure that all activities and documentation comply with global regulatory requirements.
• Perform other duties as assigned.

• 5+ years progressive experience in supply‑chain planning in the pharmaceutical industry.
• Demonstrated experience in supply planning using Kinaxis Maestro / Rapid Response.
• Experience managing and navigating a complex global supply‑chain network.
• Strong analytical and problem‑solving skills, often addressing novel/unusual situations and exercising judgement based on significant technical experience.
• Proven ability to innovate and implement practical, compliant solutions, work seamlessly across teams and develop excellent partnerships with peers.
• Demonstrated understanding of the principles and regulations associated with small‑molecule supply‑chain operations.
• Sense of urgency to deliver quality results in a highly ethical and professional manner.
• Excellent communication and interpersonal skills with the ability to communicate complex issues and solutions.
• Demon…