Vice President, Head of US Medical Affairs

Role Summary

Bicara Therapeutics is seeking an experienced and strategic Vice President, Head of US Medical Affairs to lead and shape the company's US medical affairs function. This newly created role is critical in establishing a robust scientific and clinical foundation to prepare the external landscape for the successful launch preparation and commercialization of ficerafusp alfa, Bicara’s lead asset in R/M HNSCC. The position involves building strong external relationships, providing medical insights, and ensuring the company is positioned as a credible and trusted leader in its therapeutic area.

This role is based in our Boston office and follows a hybrid schedule, with three in-office days each week.

• In alignment with global objectives, develop and execute the US medical affairs strategy aligned with the company’s global Medical Affairs and overall business and commercialization objectives, with a focus on preparing the external landscape for product launch.
• Provide scientific and clinical expertise to internal teams, external partners, healthcare professionals, and key stakeholders to inform strategies and educational initiatives that support the successful US launch of ficerafusp alfa.
• Lead, build, and manage a high‑performing Medical Affairs team within the US region.
• Foster relationships with key opinion leaders (KOLs), healthcare providers, regulatory authorities, and patient advocacy groups to build trust, credibility, and awareness around the upcoming product.
• Collaborate with Global Medical Affairs, R&D, Commercial, Regulatory, and other functions to ensure scientific accuracy, compliance, and alignment in all medical activities that influence product positioning.
• Oversee the planning and execution of scientific communications, educational programs, and medical information initiatives designed to shape the external scientific and clinical landscape in the US region.
• Provide strategic direction and oversight for US Investigator‑Initiated Trials (IITs), ensuring alignment with corporate and global medical strategies. Partner with the global IIT working group to shape research priorities and strengthen the integration of US initiatives within the global evidence‑generation framework.
• Provide medical insights to inform evidence generation activities, including observational studies, registries, and real‑world data initiatives, to demonstrate value and support market acceptance.
• Ensure all medical activities are conducted in compliance with applicable regulations, industry standards, and ethical guidelines.
• Represent the company at scientific conferences, advisory boards, and industry forums, actively positioning Bicara as a credible scientific partner ahead of product launch.
• Stay abreast of advances in the external medical landscape, competitive developments, and clinical trial outcomes to strategically position Bicara’s interests.

• Advanced degree required: MD (strongly preferred), PhD, or PharmD
• Minimum 15 years of medical affairs experience in biopharma, including leadership of launch‑stage assets
• Familiarity with oncology is advantageous
• Clinical or research expertise in oncology or rare diseases preferred
• History of building trusted KOL networks and influencing scientific communities across multiple regions
• Strong track record of evidence generation, publication leadership, and external communications
• Comfortable operating in a growth‑stage biotech environment with dynamic priorities
• Willingness to travel internationally (up to 30%) and work flexibly in a hybrid setting