Sr. Director, Real World Evidence, Global Rare Diseases

Sr. Director, Real World Evidence, Global Rare Diseases

The Senior Director, RWE is accountable for the global real-world evidence generation vision, strategy, governance, and organizational leadership for the HIDO portfolio within Global Rare Diseases (GRD). This role oversees the development and implementation of integrated evidence generation plans (IEGPs) across all HIDO assets and ensures alignment with development, regulatory, medical, market access, and commercial objectives. The Senior Director serves as the enterprise RWE leader for the HIDO portfolio, providing strategic oversight of evidence generation activities supporting marketed and pipeline products and future pipeline or acquired assets.

The position is responsible for leading the HIDO RWE organization, including management and development of the Director, RWE, and ensuring delivery of a high-impact portfolio of outcomes research, real-world evidence, patient-centered research, and post-launch evidence generation initiatives.

You'll be responsible for:

• RWE Strategy & Global Leadership
• Organizational Capability and Development
• External Partnerships and Scientific Engagement
• Scientific Methodology and Innovation
• Cross-functional Collaboration and Influence
• Operational Leadership and Governance

You will need to have an advanced degree (PhD, DrPH, MD, PharmD, MSc) in epidemiology, public health, health economics, or related field. 12+ years of experience in RWE, HEOR, epidemiology, or observational research in pharma/biotech or related setting. Demonstrated success leading global RWE and evidence generation strategy at a portfolio level, including responsibility for multiple assets across development, launch, and lifecycle management.

Proven experience developing and governing Integrated Evidence Generation Plans (IEGPs) and aligning evidence strategies with medical, regulatory, market access, and commercial objectives. Extensive knowledge of real-world data sources and secondary data analytics, including claims, electronic health records, registries, specialty pharmacy data, patient-generated data, and linked datasets. Demonstrated leadership of large-scale, multinational observational research programs, registries, and post-authorization/post-launch evidence generation initiatives.

Strong track record of influencing executive leadership and driving cross-functional decision-making through evidence-based insights. Experience supporting regulatory submissions, health technology assessment (HTA), payer interactions, market access strategies, and value demonstration initiatives through RWE. Demonstrated success establishing and managing strategic collaborations with academic institutions, research networks, data partners, patient advocacy organizations, and healthcare systems. Prior people leadership experience, including management and development of direct reports and matrix teams.

Experience leading organizational change and building RWE capabilities, processes, and governance frameworks within a global environment.

We would prefer for you to have rare disease experience strongly preferred; experience in hematology, immunology, dermatology, ophthalmology, or specialty medicines highly desirable.

Location:

Hybrid role based in Boston, MA office. Up to 20% domestic and international travel availability required.