Healthcare Compliance Operations Manager​/ Senior Manager

Healthcare Compliance Operations Manager / Senior Manager

Job Category: General & Administrative - Ionis

Requisition Number: IONIS
004065

• Posted:
  July 9, 2026
• Full-Time

MA 1 Beacon, USA ION, 1 Beacon Street 9th Floor, Boston, MA 02108, USA

HCP Engagement | Transparency Reporting | Aggregate Spend | Compliance Systems
Remote (US) — Boston, MA area preferred

This position reports to the Assistant Director, Compliance Operations, Systems & Process Lead. The Compliance Operations Manager or Senior Manager supports the day‑to‑day execution of Ionis’ Healthcare Compliance Operations activities, including HCP engagement operations, transparency reporting, compliance systems, operational data quality, reporting and dashboards, and business process execution.

This role serves as a key operational partner for core workflows, collaborating across Legal, Finance, Procurement, Medical Affairs, Commercial, IT, Privacy, and external vendors to support compliant, scalable, and efficient operations. The position also supports operational excellence through systems support, training assistance and coordination, technology enablement, and continuous improvement.

This is a remote role for candidates in the U.S., with preference given to individuals located in or near the Boston, MA area to enable periodic on‑site collaboration.

• Provide daily Healthcare Compliance Operations support and triage for operational inquiries, including compliance mailbox management, request routing, follow‑up tracking, and timely resolution.
• Support the full HCP engagement lifecycle, including business needs assessments, due diligence, FMV tiering, contracting, and payment documentation.
• Administer HCP engagement and other compliance systems, including user support, configuration coordination, testing, troubleshooting, and issue resolution.
• Support transparency reporting operations, including data collection, processing, reconciliations, validation, remediation, and reporting readiness for timely and accurate submissions under U.S. federal, state, and ex‑U.S. disclosure requirements.
• Manage operational data quality initiatives and partner with stakeholders to resolve data issues, monitor trends, and strengthen process controls.
• Develop and maintain SOPs, business rules, process maps, work instructions, FAQs, job aids, training materials, and related communications for HCP engagement and transparency reporting processes and systems; deliver end‑user training and onboarding.
• Coordinate user acceptance testing, system implementations, upgrades, enhancements, and change management activities for compliance‑related technologies and workflows.
• Track KPIs, operational metrics, dashboards, recurring reports, and trends; recommend corrective actions and process improvements.
• Develop operational reports and presentation materials using HCP engagement and transparency data.
• Identify automation and emerging digital tools, including AI‑enabled workflow solutions, to reduce manual effort, improve user experience, and strengthen controls.
• Support audit readiness, inspections, internal monitoring activities, and regulatory inquiries by maintaining accurate, complete, audit‑ready documentation, system records, and evidence of key controls.
• Support broader Compliance Operations priorities, cross‑functional projects, and other day‑to‑day operational needs as required (e.g., training and communications, compliance ambassador program, etc.).

• For the Manager position, at least 2 years of related experience in pharmaceutical, biotechnology, medical device healthcare compliance operations with a Bachelor’s degree.
• For the Senior Manager position, at least 5 years of related experience in pharmaceutical, biotechnology, medical device healthcare compliance operations with a Bachelor’s degree (or 3+ years with an advanced degree).
• Direct experience with HCP engagement, transparency reporting, and compliance systems administration.
• Strong understanding of HCP engagement lifecycle activities, including business needs assessments, FMV tiering, due diligence, contracting, payment…