Senior Scientist, Medicinal Chemistry -Lead Generation

Overview

Monte Rosa Therapeutics (MRT) seeks to recruit an enthusiastic, creative and highly talented medicinal chemist who is eager to discover molecular glue degraders (MGDs) that eliminate disease-causing proteins previously thought undruggable.

This position plays a key role in advancing our drug discovery projects from Lead Identification through development candidate nomination and beyond, while also enhancing the MRT degradation platform. The successful candidate should have state-of the-art medicinal chemistry expertise in small molecule drug discovery, prior experience collaborating in multi-disciplinary teams, and a passion for advancing projects towards clinical development candidates.

• Devise and implement medicinal chemistry strategies to advance projects from hit validation through lead optimization to development candidates
• Analyze High Throughput Screening (HTS) output with the goal of identifying promising starting points for hit generation chemistry from our growing MGD library
• Develop hit follow up and lead generation strategy for discovery targets in collaboration with discovery scientists
• Provide chemistry progressability assessments for early targets
• Familiarity with key concepts and optimization strategies in medicinal chemistry including a clear understanding of ADME properties
• Serve as chemistry project lead for protein degradation projects
• Efficient and timely execution of compound syntheses through our CRO network, by devising efficient synthetic routes
• Collaborate with external research partners
• Communicate scientific findings and project updates to senior leadership and governance
• Summarize and publish findings in manuscripts and patents when appropriate

• PhD in synthetic organic/medicinal chemistry with 4+ years of experience in pharmaceutical/biotech industry, or MS with 8+ years of experience is acceptable
• Experience in the field of Targeted Protein Degradation is preferred
• Strong expertise in High-Throughput Screening (DEL, ASMS, etc) analysis and subsequent follow-up studies
• Experience of managing CROs is essential
• Familiarity with early stages of pre-clinical research in drug discovery
• High level of proficiency with databases, data analysis and visualization tools
• Proficiency in complex molecule synthesis and/or synthetic method development experience
• Excellent teamwork skills and the ability to work effectively in global, cross-disciplinary drug discovery teams (biochemistry, biology, structural biology, CADD, and DMPK)
• Excellent written and oral communication skills