ADME Scientist

The ADME Scientist will help build and execute the next-generation platform. They will play a role critical in accelerating the drug discovery pipeline by providing timely and high-quality in vitro ADME data to guide lead optimization.

• Design, develop, optimize, and validate a wide array of high-throughput in vitro ADME assays
• Working with automated liquid handlers such as Hamilton, Lynx, Bravo, and Formulatrix.
• Develop and perform mass spectrometry analysis of samples from ADME assays.
• Method development and troubleshooting.
• Ensure proper sample preparation and management for high-throughput analysis.
• Analyze, interpret, and report complex ADME data, including calculating key pharmacokinetic parameters.
• Present results and provide expert recommendations to medicinal chemists and project teams.
• Maintain detailed and accurate laboratory records, SOPs, and electronic notebooks.
• Ensure all laboratory activities comply with internal quality standards and safety regulations.

• Ph.D. in Pharmaceutical Sciences, Pharmacology, Analytical Chemistry, or a related field with 2+ years of relevant industry experience, or a Master's degree with 5+ years of industry experience.
• Extensive, hands‑on experience with LC-MS or acoustic MS particularly in a high‑throughput setting.
• Proven track record in developing and running automated in vitro ADME assays using state‑of‑the‑art laboratory automation.
• Strong theoretical and practical knowledge of drug metabolism pathways and DMPK.
• Familiarity with common ADME prediction software and data visualization tools.

• Experience using lab automation.
• Programmatic coding experience (e.g., Python, R, or similar).
• Data visualization (Spotfire, Python, R, or similar).
• Experience handling clinical samples.
• Familiarity with working in a CRO (Contract Research Organization) environment or managing CRO relationships.
• Proficiency with electronic laboratory data capture systems (e.g., LIMS, ELN).