Postdoctoral Associate, Pharmacology, Physiology & Biophysics, Chobanian & Avedisian School of Medicine

The TCW laboratory ((Use the "Apply for this Job" box below).) in the Department of Pharmacology, Physiology & Biophysics at Boston University Chobanian & Avedisian School of Medicine in Boston, Massachusetts is looking for highly motivated and skilled stem cell biologists or electrophysiologists to be the drivers of our efforts to translate the genetics of human AD toward therapeutic interventions.

The core program is to translate AD genetics and functional genomics into human brain cells both in vitro 2D and 3D models using human induced pluripotent stem cells (hiPSCs) from population and isogenic lines generated by CRISPR/Cas9 genome editing and in vivo hiPSC/rodent chimera systems in comparison with post-mortem brain. In particular, the research will focus on deciphering the molecular mechanism of major AD risk variants as well as protective variants, associated genes and identifying targeted therapeutics.

Furthermore, the research focusing on human iPSC-glial transplantation in AD animal models followed by in vivo electrophysiological and behavior readouts will enable potential stem cell therapeutics. The candidate will join a multidisciplinary and highly collaborative research team that includes computational geneticists, neuroscientists and pharmacologists in the department as well as Genome Science Institute and Center for Systems Neuroscience at Boston University.

Interested candidates should submit a cover letter outlining their research interests and career goals, a current CV, and contact information for three references to Dr. Julia TCW, Assistant professor and Director [juliatcw] or .

Review of applications will begin immediately and continue until the position is filled.

Required Skills

* Experienced in handling stem cells (mouse or human iPSCs, embryonic stem cells) and any cell type differentiation (2D or 3D cell cultures), or Experienced in electrophysiology (in vivo ephys, Ca imaging, MEA, path clamping), animal behaviors
* (Plus) CRISPRa/i screens, genome-editing

* Clear written and oral communication and detailed documentation skills, with the ability to collaborate effectively across disciplines

We are an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, natural or protective hairstyle, religion, sex, age, national origin, physical or mental disability, sexual orientation, gender identity, genetic information, military service, pregnancy or pregnancy-related condition, or because of marital, parental, or veteran status. We are a VEVRAA Federal Contractor.