Senior Director, AIRx Biochemistry - In Vitro Biology Lead

Job Description

Takeda Research is constructing a Lab of Tomorrow built on AI, automation, new ways of working, and talent with the singular vision of delivering differentiated medicines to the clinic at speed and cost. To catalyze these efforts, Takeda is creating two complementary units: AI Research Accelerator (AIRx) and Discovery Automation & Robotics (DAR).

AIRx will consist of a dedicated group of experienced drug hunters with the autonomy of a biotech and the resources of a leading pharmaceutical company. It is designed to incubate the future AI-powered operating models and deliver candidates to the clinic at industry leading speed and success rates.

The Biochemist owns the in vitro pharmacology cascade for all AIRx programs. This scientist defines the testing strategy, oversees externalized assay execution through CRO partners, and ensures all biochemical and cellular data generated is high-quality, reproducible, and directly informing go/no‑go decisions.

This role operates at the intersection of classical pharmacology and AI-enabled data analysis — integrating experimental outputs into the AIRx DMTA loop and contributing to the broader data infrastructure that powers AI-enabled insights generation.

• Design and own the in vitro pharmacology cascade for all AIRx programs across both project teams
• Define CRO assay specifications; provide scientific oversight of externalized assay execution; critically interpret biochemical and cellular data packages
• Integrate biochemical data into AI-enabled DMTA cycles; partner with Computational and Medicinal Chemistry to close design loops rapidly
• Ensure data quality, reproducibility, and standardization across external biology partners; leverage SAIL and Aedifica Fortis platforms for data ingestion and analysis
• Contribute to safety, selectivity, and mechanistic profiling strategies in coordination with internal Safety and DMPK contacts
• Provide scientific input to PRC presentations and governance decision‑making forums
• Contribute to harmonization of assay data across sources to support AI model training and insights generation
• Maintain awareness of relevant biochemistry literature and emerging assay technologies to continuously improve the testing cascade

• PhD in biochemistry, pharmacology, or cell biology
• 12‑15+ years of drug discovery experience with hands‑on expertise in biochemical and cell‑based assay development and interpretation
• Proven track record designing and managing externalized CRO biochemistry and pharmacology programs
• Ability to critically evaluate and integrate large in‑vitro datasets from multiple external sources
• Experience in at least one therapeutic area represented across the Takeda Research portfolio
• Experience with AI/ML data analysis platforms preferred (e.g., automated data pipelines, Tetra Science)
• Background in mechanistic and MoA‑level characterization alongside standard binding/enzyme/cell assays
• Strong cross‑functional collaboration skills; able to work at pace in a lean team environment

• The position will be based in Cambridge, MA. This position is currently classified as “hybrid” by Takeda’s Hybrid and Remote Work policy

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

Boston, MA

$ – $

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.

The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short‑term and/or long‑term incentives. U.S. based…