Director, Medicinal Chemistry & Target Validation

Responsibilities

• Drive state‑of‑the‑art multi‑parameter medicinal chemistry optimization with creativity, innovation, in-depth analysis of data, and existing literature information
• Contribute in a very impactful manner to compound design and synthetic route identification for all portfolio projects
• Lead medicinal chemistry efforts on validating targets at early stage to clear decision point
• Holistic approach to hit/lead finding including use of structure‑based drug design and fragment‑based drug discovery
• Effective leadership and management of CRO chemistry teams through excellent synthetic and medicinal chemistry skills with clear and open communication
• Lead medicinal chemistry efforts and contribute beyond med chem as part of a multi‑disciplinary project team
• Represent the company effectively in scientific matters to external organizations.
• Provide mentorship, guidance, and development for junior project leaders and medicinal chemists.

• PhD in organic/medicinal chemistry with 8+ years of experience as a medicinal chemist/project leader in the biotech/pharmaceutical industry with a track‑record of leading/contributing to research projects towards IND‑track nomination
• Extensive knowledge of modern medicinal chemistry strategies for the optimization of DMPK, biochemical, pharmacological and safety
• Excellent synthetic organic chemistry skills and creativity are required.
• Proven ability as chemistry leader, contributing beyond med chem as part of a multi‑disciplinary project team
• Proven ability as chemistry leader on validating or prioritizing targets with conclusive data package
• Demonstrated ability to work collaboratively with cross‑functional teams
• Willingness to be both a strategic leader and a hands‑on problem solver
• Excellent organizational skills, ability to multi‑task in an extremely fast‑paced environment with changing priorities while maintaining attention to detail
• Ability to communicate clearly and concisely with all stakeholders

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market‑based, performance‑driven pay.
• The anticipated base salary range for this role is $195,000 – $275,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Equal Employment Opportunity

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.