Senior Research Technician

The Targeted Protein Degradation (TPD) Proteomics Core within the Fischer Lab at Dana‑Farber Cancer Institute serves as a resource for the Cancer Biology Department, aiding investigators in answering key research questions using mass spectrometry‑based proteomics.

We employ quantitative chemoproteomic and interactomic approaches to identify drug targets and are expanding our repertoire to meet the needs of our core users. The core is equipped with advanced mass spectrometry equipment including tims

TOF HT, tims

TOF Ultra2 and Orbitrap Eclipse tribrid mass spectrometers.

The TPD Core seeks a highly motivated individual to join the team as a Senior Research Technician, who will employ mass spectrometry‑based technologies to assess the cellular proteome in response to external stimuli and work with technicians, scientists, postdocs and students on research projects focused on targeted protein degradation.

The Institute is located in Boston and the surrounding communities.

• Responsible for cell culture and performing drug treatments
• Perform proteomics sample preparation including cell lysis, digestion, peptide cleanup (e.g. S‑Trap, SP3), and labeling (e.g. TMT)
• Run samples on LC‑MS systems (e.g. Orbitrap, tims
  
  TOF) following standard protocols
• Support routine QC checks and instrument maintenance under staff supervision
• Maintain accurate and well‑organized lab notebooks and sample metadata
• Collaborate with core users to ensure timely sample processing and communication
• Assist in the implementation of new protocols and improvements to existing workflows
• Help train junior staff and contribute to a clean and safe laboratory environment
• Maintain and order laboratory supplies
• Communicate with purchasing and may be responsible for negotiating with vendors

• Bachelor’s degree in biology, chemistry, or related field.
• 1–4 years of experience in a mass spectrometry or molecular biology lab (academic or industry).
• Experience operating Thermo and/or Bruker mass spectrometers is required.
• Experience with mammalian cell culture and proteomics sample preparation is preferred.
• Experience in mass spectrometry data analysis and quantitative methods.
• Knowledge of statistical and computational methods and R programming is preferred.
• Knowledge of proteomics data analysis software, including Proteome Discoverer, DIANN, Spectronaut.
• Strong attention to detail and ability to follow SOPs.

Dana‑Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

$52,400.00 - $57,200.00