Senior Director; Senior Principal Scientist), Translational Medicine, Immunology

Overview

Senior Principal Scientist (Senior Medical Director) – Translational Medicine, Immunology. This role plans and manages a critical inflection point in drug development, translating preclinical discovery into compounds ready for large‑scale clinical assessment. The position requires a physician‑scientist with a proven track record in the pharmaceutical industry and independent academic research, focusing on Immunology R&D and clinical expertise in fields such as Dermatology, Rheumatology, or Gastroenterology.

• Lead the development and execution of early clinical development strategy for novel Immunology assets, including Phase 1a/b trials and clinical pharmacology studies from Preclinical Candidate approval through Phase 2a Proof‑of‑Concept.
• Partner with discovery research teams to identify novel targets and provide clinical insight at the earliest stages of target identification and validation.
• Develop biomarker strategies across cross‑functional teams, executing Experimental Medicine studies to validate new clinical biomarker platforms.
• Ensure safe and timely execution of Phase I studies and coordinate with internal and external clinical study support staff.
• Provide clinical pharmacology support for programs through worldwide marketing application filings, including supportive registration documents and presentations.
• Communicate and interpret study results to therapeutic area governance, functional area experts, and development review committees.
• Collaborate with key functions such as Discovery Sciences, Preclinical Pharmacology, Pharmaceutical Sciences, Toxicology, Translational Biomarkers, and late‑stage Clinical Research across sites in the USA, UK, and Belgium.

• MD or MD/PhD degree.
• Minimum 5‑year experience in the pharmaceutical industry, preferably in immunology clinical research, including translational research.
• Track record of independently conceived and executed research and clinical patient care experience.
• Proven expertise in clinical research within the pharmaceutical sector and clinical care of patient populations in Dermatology, Rheumatology, or Gastroenterology.
• Strong interpersonal, written, and presentation skills with the ability to work collaboratively in a team environment.
• Board certification or eligibility (MD or MD/PhD) preferred.

• Academic research experience in any immunology field.
• Experience with Clinical Trial Development, Drug Development, Gastroenterology, Immunology, and Translational Research.
• Demonstrated record of scientific publications and research achievements.

• Salary range: $ – $.
• Eligibility for annual bonus and long‑term incentive, if applicable.
• Comprehensive benefits package, including medical, dental, vision, retirement with 401(k), paid holidays, vacation, and compassionate and sick days.
• Relocation assistance for domestic candidates.
• Hybrid work arrangements available.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination based on race, color, age, religion, sex, sexual orientation, gender identity, national origin, veteran status, disability status, or other legally protected characteristics. We comply with all affirmative action requirements as a federal contractor.