Analytical Development - Molecular Biologist

Job Description

The position supports an Analytical Development client team responsible for the characterization and testing of raw materials, RNA drug substances, and LNP drug products at different stages of development. The successful candidate will work closely with Quality Control, Quality Assurance, Process Development, and R&D groups to advance preclinical gene editing candidates and support a growing gene editing pipeline.

• Perform molecular biology techniques such as qPCR, d/ddPCR, and work with DNA/RNA material to perform extraction, purification, reverse transcription, amplification, fragment size assessments, electrophoresis methods, and enzymatic manipulation reactions.
• Develop and qualify phase-appropriate analytical methods from the analytical research team for activities including release and stability testing, product characterization, high-throughput analysis, and characterization of complex raw materials.
• Potentially execute techniques including sterile tissue culture, maintenance of mammalian cell culture preps, and cell-based assays.
• Potentially execute NGS (next generation sequencing) workflows including library preparation.
• Collect, process, and analyze experimental data, ensuring accurate and timely documentation in an electronic laboratory notebook (ELN).
• Review, interpret, and present data within the analytical team and cross-functionally.
• Maintain laboratory equipment and order critical reagents.
• Other duties as assigned.

• B.S./M.S. in Biological Sciences/Pharmaceutical Sciences, Biochemistry, Chemistry, Analytical Chemistry, or related field with at least 3 years of relevant laboratory industry experience.
• Proficiency with molecular biology techniques including DNA/RNA electrophoresis methods, DNA amplification methods, various DNA/RNA enzymatic manipulations, cloning, DNA/RNA purification techniques, DNA/RNA fragment size assessment techniques, and dPCR/ddPCR.
• Hands-on experience with NGS library preparation workflows for Illumina, Pac Bio, and Oxford Nanopore sequencing platforms.
• Familiarity with sequence analysis software such as Snap Gene or equivalent.
• Strong pipetting technique and meticulous attention to detail in laboratory settings.
• Strong aseptic technique with hands-on mammalian cell culture experience.
• Accurate and timely documentation practices with experience using an electronic laboratory notebook (ELN).

• Experience with biophysical instrumentation such as DLS, Osmometer, pH, and basic fluorescence-based assays.
• Hands-on experience with Illumina sequencers such as Miseq/Nextseq, and Oxford Nanopore sequencer MinION.
• Basic knowledge of Linux environment and understanding of NGS data analysis in the Linux command line.
• Experience working with oligonucleotides or lipid nanoparticle (LNP) products and formulations.
• Experience in a QC GMP environment with strong documentation and pipetting skills.
• Familiarity with gene editing techniques and related analytical methods.
• Direct experience with statistical analysis tools.
• Experience performing workflows using automation platforms.
• Strong understanding of analytical methodology and development.
• Authorization to work in the United States indefinitely without restriction or sponsorship.

The position is full-time, Monday-Friday, 8am-5pm with overtime as needed. Candidates living within a commutable distance of Boston, MA are encouraged to apply.

Excellent full-time benefits include:

• Comprehensive medical coverage, dental, and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays
• Eligibility for yearly goal-based bonus & merit-based increases
• Compensation: $35.00-$41.00 per hour

Eurofins USA PSS Insourcing Solutions is an Equal Employment Opportunity employer.