Senior​/Principal Scientist, Biologics Cell Line Development

Our mission at Asimov is to advance humanity’s ability to design living systems, enabling biotechnologies with outsized benefit to society. We’re developing a mammalian synthetic biology platform––from cells to software––to enable the design and manufacture of next-generation therapeutics.

We are seeking a Senior or Principal Scientist, commensurate with experience, to join our Biologics Cell Line Development team in Boston, MA and help push the boundaries of biotherapeutic cell line development. This role is for a scientific innovator and a manager of junior scientists. The successful candidate will conduct & supervise CHO-based cell line development for biologic therapeutics moving into clinical development.

Significant effort designing complex experimental approaches to improve expression systems and workflows through innovation and implementation of new technology is also an important part of this role.

The successful candidate will also work cross-functionally with Asimov’s synthetic biology, modeling, process development and analytical teams. This is a unique opportunity to work at a nimble, forward-thinking synthetic biology startup and help build the future of biological engineering.

• You’ll perform CHO cell line development processes including transfection, cloning, characterization, and cell banking using state-of-the-art equipment.

• You’ll drive innovation through the development of improved genetic components, host cell line engineering and cell line development process optimization.

• You’ll identify emerging practices for biologics cell line development and manufacturing to shape scientific strategies and continued innovation.

• You’ll represent the cell line development team on cross-functional projects, making decisions for cell line activities and effectively communicating results, progress and plans.

• You’ll represent Asimov externally, contributing to industry conferences, industry forums, filing patents, and publishing peer-reviewed manuscripts.

• You’ll manage and mentor a team of 3+ scientists focused on CHO-based biologics CLD, providing technical direction and supporting them in their professional development.

• Experience of 5+ years CHO-based cell line development is a must, stemming from expressing IgGs and bispecifics in an industrial CLD environment.

• You have a Ph.D. in Biological Engineering, Cell Biology, Molecular Biology, or a related field.

• You’re a creative problem solver never satisfied with the status quo and get excited about the opportunity to drive the creation of disruptive technology.

• Minimum 1 year experience managing direct report(s) and providing technical guidance.

• Don’t let this stop you from applying, but it’s a plus if you are familiar with any of the following: vector optimization to improve titer and product quality attributes for complex bispecific scaffolds; CLD process optimization; or development of automated high-throughput screening for CLD workflows.

• Experience working with a global customer base isn’t a requirement for this role but bonus points if you have it.

$145K – $190K

This role may be hired at the Senior Scientist or Principal Scientist level. The base salary hiring range for Senior Scientist candidates is expected to be $145,000 to $165,000 annually, and for Principal Scientist candidates $170,000 to $190,000 annually. The base salary offered may vary based on factors such as the final candidate’s relevant knowledge, skills and experience for the role.

Our total rewards package also includes the opportunity for stock options, eligibility for our 401(k) plan, medical, dental, vision, life and disability insurances, as well as a career development stipend. Our robust time-off policy includes flexible time-off and unlimited sick time. We will talk about compensation in our first conversation and be transparent throughout the process about which level we think is the best match for you in our organization.