Research Scientist PDL Lab

Site:
The General Hospital Corporation

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

The Massachusetts General Hospital Cancer Center’s Process Development Laboratory seeks a full-time Process Development Scientist I to support and advance its translational cell and gene therapy research platform. The Process Development Laboratory is a highly integrated, innovation-driven facility dedicated to translating next-generation cellular immunotherapy and gene engineering technologies into clinically deployable manufacturing solutions. This position offers an exceptional opportunity for an independent and motivated scientist to serve as a scientific lead within a multidisciplinary translational team, working at the interface of biology, engineering, manufacturing science, and regulatory strategy.

The successful candidate will contribute to the design, development, optimization, and clinical translation of novel manufacturing workflows poised for IND-enabling studies and early-phase clinical trials, while operating in a collaborative academic medical center environment.

In consultation with their Principal Investigator (PI), undertake and execute a program of scientific study culminating in publication. Drives research projects scientifically and determines the course of research as evidenced by leadership, obtaining funding, writing, or other recognition. May not necessarily receive independent resources; however, their contribution is essential to the conceptual/scientific success of the project. They assist their PI in the training and supervision of other laboratory personnel and in a wide variety of administrative tasks, as necessary.

Does this position require Patient Care? No

• Makes proficient intellectual contributions to scientific strategies of the group/lab and plays a leadership role by acting as subject matter authority in the field.
• Contributes to the design and execution of experiments and/or research projects.
• Exercises judgment in selecting methods and technologies to obtain results.
• May collaborate with external researchers and/or receive external project funding support.
• Presents results and prepares publications.
• May assist PI in the training and supervision of other staff.

Education:

Doctorate Related Field of Study required

Can this role accept experience in lieu of a degree? No

Licenses and Credentials: N/A

Previous Research experience (inclusive of graduate and postdoctoral experience) 5-7 years required

• Excellent research skills.
• Demonstrated evidence of specific scientific competence in field.
• Demonstrated broad knowledge of field.
• Evidence of potential for scientific creativity and original thought.
• Able to exercise independent judgment and leadership.
• Ability to contribute to publications.

• Demonstrated experience in cell and/or gene therapy research and process development.
• Hands‑on experience working with primary human cells, preferably immune effector cells.
• Strong foundation in cell culture, molecular biology, and translational experimental design.
• Experience with CAR T-cell or immune effector cell manufacturing.
• Familiarity with CRISPR/Cas-based genome editing technologies.
• Experience with viral vector production or gene delivery platforms.
• Exposure to cGMP environments, IND-enabling studies, or regulated manufacturing settings.
• Experience with closed-system or automated manufacturing platforms.
• Prior experience contributing to regulatory documentation, technology transfer, or validation activities.

Onsite

149 Thirteenth Street Building 149

40

Regular

Day (United States of America)