Scientist , In Vivo

Jnana Therapeutics is a clinical-stage biotechnology company leveraging its next-generation chemo proteomics RAPID platform to discover medicines for highly validated, challenging-to-drug targets to treat diseases with high unmet need. Jnana is focused on developing first- and best-in-class therapies to treat a wide range of diseases, including immune-mediated and rare diseases. Jnana's lead program is a potential first-in-class oral approach, targeting an allosteric site on the phenylalanine transporter SLC6A19, for the treatment of phenylketonuria (PKU), a rare genetic metabolic disease.

Located in Boston, Jnana brings together scientific leaders in small molecule drug discovery and development, a highly experienced management team and the backing of its parent company, Otsuka Pharmaceuticals.

Jnana Therapeutics is seeking an enthusiastic and highly motivated In Vivo Biologist to work in our multidisciplinary Translational Pharmacology group. At Jnana, we use our novel hit generation platform with a range of cell-based assays, our research aims to unlock difficult to drug targets. This opportunity is for an individual who strives to innovate and is never satisfied with routine. This person will be collaborating with Biology and Chemistry groups to design and implement mouse models of PK/PD and efficacy for autoimmune diseases.

Prior experience in drug discovery, particularly in the area of autoimmune disease models, cytokine analysis and multi-color flow cytometry is desired. Must have strong technical experience handling, dosing, and sampling from mice. Strong commitment and work ethic are essential.

• Assist in design and implement acute PK/PD models to screen novel compounds for autoimmune targets.
• Validate and utilize mouse models of autoimmune disease including models of colitis, SLE, atopic dermatitis, psoriasis and asthma to interrogate novel compounds.
• Ex-vivo assessment of study samples using MSD, ELISA, and multi-color flow cytometric analysis.
• Must be able to work with project teams as an In Vivo Lead to understand project goals and collaborate on how to address them.
• Occasional weekend monitoring/dosing of studies.

• MS in Pharmacology, Biology, or other relevant area with 5+ years of industry experience or PhD in Pharmacology, Biology or other relevant area with 0-2 years industry experience.
• Must be competent in IV, PO, SC and IP dosing of mice, in-life, and terminal blood collections.
• Experience running PK/PD models and mouse models of autoimmune disease.
• Many different techniques will be used, and training may be provided, but a desire to quickly gain independence is important.
• Demonstrate strong communication skills and attention to detail.
  
  Must be a scientifically motivated self-starter, able to work effectively in a fast-paced team environment.