Senior Scientist – In Vivo Neuroimmunology

Overview

Our company's Neuroscience is recruiting a Sr. Scientist in the Neuroimmunology team in Boston, MA to lead in vivo model development and validation to advance novel immune‑based therapies for CNS diseases. The role involves evaluating PK/PD and disease‑relevant endpoints in murine models, designing and executing studies, analyzing data, and communicating results to cross‑functional teams.

• Design, execute, and report murine in vivo studies addressing target validation, mechanism of action, PK/PD, and translational biomarkers; take end‑to‑end ownership of study planning and documentation.
• Perform and supervise dosing (IV, IP, PO, SC and other routes), blood collection, cardiac perfusion, and careful dissection/collection of CNS and peripheral tissues.
• Prepare and fractionate tissues for biochemical and molecular assays (soluble/insoluble protein fractions) and execute immunoassays and RNA analyses (e.g. ELISA, OLINK, NULISA, western blot, flow cytometry, qPCR/RT‑qPCR, bulk and single‑cell RNA sequencing).
• Process, curate, and analyze datasets; apply statistical and computational tools to generate figures, study reports, and presentations that inform program decisions.
• Troubleshoot and optimize experimental and analytical workflows, validate new methods, ensure reproducibility, and maintain accurate records.
• Communicate results clearly to project teams and the broader scientific community (internal reports, presentations, and publications), and uphold laboratory safety, animal welfare and regulatory compliance while collaborating across functions and with external partners.

This is an on‑site laboratory position based in Boston. Occasional travel (