Senior Scientist, Computational Protein Design

Position Summary

We are seeking a Protein Design Scientist to join the Computational Protein Design team and help drive structure-based design and optimization of synthetic proteins. This is a highly interdisciplinary role at the interface of computational design, structural biology, and protein engineering.

• Design and execute SynteinsTM engineering campaigns to generate drug candidates.
• Create computational design strategies to deliver drug candidates drawing from an array of ML tools and Rosetta scripts.
• Collaborate with computation, chemistry, and experimental biology teams to optimize designs for function, solubility, and stability.
• Integrate structural and biophysical data (e.g., binding, CD, HDX-MS, CryoEM) into iterative optimization cycles.

Required

• PhD in structural biology, biophysics, protein design, or related field.
• 2+ years of hands‑on experience in structure‑guided protein design.
• Demonstrated proficiency with modern structure prediction and design tools such as RF diffusion, proteinMPNN, AF2, Boltz2, Boltz Gen, Rosetta or equivalent state‑of‑the‑art tools for in‑silico protein engineering.
• Strong understanding of the biophysics of protein folding and interface energetics.
• Demonstrated ability to progress designs from concept to experimental testing.
• Excellent communication skills.

Preferred

• Experience designing mini binders or proteins