Senior Scientist – In Vivo Neuroimmunology

Job Description

Our company's Neuroscience is recruiting a Senior Scientist in our Neuroimmunology team in Boston, MA to lead in vivo model development and validation to advance novel immune-based therapies for CNS diseases.

As a Senior Scientist, you will apply your expertise to evaluate PK/PD and disease-relevant endpoints in murine models to advance pipeline programs. This lab‑based role requires independent ownership of study design, execution, sample processing and evaluation, data analysis, and clear communication of results to cross‑functional project teams and stakeholders. The successful candidate will work independently as well as proactively collaborate with colleagues to generate high‑impact data that drive decision making and advance drug discovery.

• Design, execute, and report murine in vivo studies addressing target validation, mechanism of action, PK/PD, and translational biomarkers; take end‑to‑end ownership of study planning and documentation.
• Perform and supervise dosing (IV, IP, PO, SC and other routes), blood collection, cardiac perfusion, and careful dissection/collection of CNS and peripheral tissues.
• Prepare and fractionate tissues for biochemical and molecular assays (soluble/insoluble protein fractions) and execute immunoassays and RNA analyses (e.g. ELISA, OLINK, NULISA, western blot, flow cytometry, qPCR/RT‑qPCR, bulk and single‑cell RNA sequencing).
• Process, curate, and analyze datasets; apply statistical and computational tools to generate figures, study reports and presentations that inform program decisions.
• Troubleshoot and optimize experimental and analytical workflows, validate new methods, ensure reproducibility, and maintain accurate records.
• Communicate results clearly to project teams and the broader scientific community (internal reports, presentations, and publications), and uphold laboratory safety, animal welfare and regulatory compliance while collaborating across functions and with external partners.

This is an on‑site, laboratory position based in Boston. Occasional travel (under 10%) may be required.

• Master's (with 5+ years of experience) or Ph.D. (with 1 year of experience) in Neuroscience, Molecular Cell Biology, Pharmacology, Biology, or related field with relevant experience.

• Demonstrated hands‑on experience designing and executing rodent in vivo experiments, including stereotaxic surgeries (intracerebral and intracerebroventricular injections).
• Proficiency with multiple routes of dosing, blood collection methods, cardiac perfusion, and dissection of CNS (discrete brain regions, spinal cord) and peripheral tissues.
• Practical experience preparing tissue fractions (soluble/insoluble proteins) and performing biochemical and molecular assays (e.g. ELISA, OLINK, NULISA, western blot, RNA sequencing or qPCR).
• Experience independently analyzing and visualizing experimental data including from multiplexed platforms.
• Strong written and oral communication skills; ability to prepare study reports and present findings to diverse audiences.
• Ability to work independently within a collaborative, cross‑functional team.

• Industry drug‑discovery experience in pharmaceutical or biotech settings.
• Hands‑on proficiency with murine procedures including CSF collection and osmotic‑pump implantation/management.
• Experience with inflammatory and neurodegenerative transgenic mouse models or with PK/PD and dose–response study design/interpretation.
• Experience designing and executing sequencing studies (e.g., bulk RNA‑seq, scRNA‑seq or snRNA‑seq), working knowledge of data analysis tools (Python and/or RStudio preferred) and experience generating figures/reports.
• Experience mentoring or supervising early‑career scientists and collaborating across functional teams.
• Record of contributions to scientific publications or presentations.

Benefits include medical, dental, vision coverage, retirement plans, paid holidays, vacation, and compassionate leave.

Salary range: $ – $. Eligible for annual bonus and long‑term incentive, if applicable.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. We comply with affirmative action requirements. For more information about personal rights under U.S. Equal Opportunity Employment laws, visit EEOC resources.