Sr Scientist​/Principal Scientist - Genomics Sciences

Senior Experimental Genomics Expert

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve.

This is hard, urgent, selfless work—but it's work worth doing. If you're driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

The Genomic Sciences team within Lilly Genetic Medicine/RNA Therapeutics is seeking a senior experimental genomics expert to lead and execute genomics assays in support of the discovery and development of RNA medicines. This role is embedded in a high-throughput genomics screening environment that generates decisional data for siRNA and antisense oligonucleotide programs across the LGM portfolio. The successful candidate will be a hands-on experimentalist with strong technical skills in next-generation sequencing (NGS), a commitment to rigorous sample management and documentation, and a desire to contribute meaningfully to the advancement of genetic medicines.

Key Responsibilities:

• Execute and optimize NGS library preparation workflows (e.g., 3' RNA-seq, mRNA-seq, etc.) across targeted and large-scale screening campaigns, maintaining high quality and throughput
• Track, document, and QC samples through all stages of assay development
• Develop, troubleshoot, and refine genomics assay protocols to meet evolving program needs, including new library chemistries, multiplexing strategies, and sample input optimization
• Maintain impeccable sample tracking, chain-of-custody documentation, and electronic lab notebook records in compliance with Lilly quality standards
• Collaborate closely with computational genomics, medicinal chemistry, and biology colleagues to ensure experimental designs generate robust, interpretable, and decisional data
• Participate actively in cross-functional project teams, contributing scientific perspective on assay design, data interpretation, and experimental prioritization
• Support lab infrastructure including reagent inventory, equipment maintenance, and continuous improvement of standard operating procedures

Basic Qualifications:

• Bachelor's degree in genomics, molecular biology, biochemistry, genetics, or a related discipline with a minimum of 3+ years of relevant laboratory experience; OR Master's degree in genomics, molecular biology, biochemistry, genetics, or a related discipline with a minimum of 1+ years of relevant laboratory experience
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1

Preferred Qualifications:

• Demonstrated hands-on experience with NGS library preparation, quality control (Qubit, Tape Station/Bioanalyzer, qPCR-based quantification), and sequencer operation
• Strong organizational skills with meticulous attention to sample management, documentation, and experimental reproducibility
• Ability to work effectively in a fast-paced, team-oriented research environment generating high-quality decisional data at scale
• Experience with high-throughput or pooled screening workflows in a pharmaceutical or genomics core environment
• Experience with singe cell genomics or spatial transcriptomics data
• Familiarity with RNA therapeutics biology (siRNA, ASO) and associated transcriptomic readouts
• Bioinformatics experience including comfort with command-line tools, scripting (R, Python), and/or analysis of NGS data (alignment, QC metrics, differential expression)
• Experience with automation platforms (e.g., Hamilton, Beckman) for library preparation or sample handling
• Track record of method development or assay optimization in a research or development setting
• Experience using and developing ELN based…