Post-Doctoral Research Fellow – Functional Genomics

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Massachusetts General Physicians Organization, Inc.

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Please send your CV/Resume and Cover Letter directly to: du, du, and du for this position. A linked application is not available.

The Talkowski Laboratory in the Center for Genomic Medicine (CGM) at Massachusetts General Hospital (MGH), Harvard Medical School, and the Broad Institute is seeking exceptional postdoctoral candidates in computational biology, bioinformatics, and/or statistical genetics. Candidates would direct collaborative research initiatives seeking to determine the functional impact of genomic variations in developmental, neuropsychiatric, and neurodegenerative disorders.

Highly qualified candidates would oversee one or more of the following studies:

• Functional genomics analyses from human iPSC‑derived neuronal cells or three‑dimensional organoid models modified using CRISPR/Cas9 genome editing.
• Multi‑omics data integration to define the functional impact of genomic variation and editing across neuronal models of developmental, neuropsychiatric, and neurodegenerative disorders.
• Mechanistic interpretation of molecular signatures to uncover therapeutically actionable targets.

At the Broad Institute, these collaborative projects span the Stanley Center for Psychiatric Research, and the Program in Medical and Population Genetics. Candidates work with cutting‑edge data types such as single‑cell transcriptome sequencing, Hi‑C studies of 3D topology, ATAC‑seq, 4C‑seq, and other datasets in iPSC‑derived neurons and organoid models of neurodevelopment. They develop systematic computational frameworks for the integration and mechanistic interpretation of large‑scale genomics datasets, synthesizing multi‑omics signals into coherent biological models that reveal the molecular underpinnings of disease.

These efforts drive the identification and prioritization of high‑confidence targets for downstream molecular investigation and therapeutic development.

The Postdoctoral Fellow will be based at MGH under the guidance and mentorship of Dr. Michael Talkowski.

Visa sponsorship is available for Postdoctoral Fellows.

SKILLS & COMPETENCIES

REQUIRED:

• First (or co‑first) author of one or more peer‑reviewed scientific publications.
• Excellent English verbal and written communication skills.
• Able to work both independently and in a team.
• Experience with commonly used bioinformatics tools and databases.
• Programming skills (i.e., R, Python, C++, etc.).
• Advanced knowledge of statistical methods.
• Knowledge of neurobiology is a huge plus.
• Expertise in analyzing next‑generation sequencing data (i.e., WGS, WES, RNA‑seq, ATAC‑seq, ChIP‑seq, scRNA‑seq, etc.).

LICENSES, CERTIFICATIONS, and/or REGISTRATIONS:
Not Applicable

EDUCATION:

Minimum

Required:

Doctoral Degree. Preferred:
Doctoral Degree.

FIELD OF STUDY / ADDITIONAL SPECIALIZED TRAINING:
Not Applicable

EQUIVALENT

EXPERIENCE:

Not Applicable

EXPERIENCE:

Required:

Recent PhD graduate.

SUPERVISORY RESPONSIBILITY:
Not Applicable

FISCAL RESPONSIBILITY:
Not Applicable

Remote Type: Onsite

Work Location: 55 Fruit Street

EEO Statement: 1300 Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and…