Sr Scientist​/Principal Scientist - Genomics Sciences

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Job Description:

The Genomic Sciences team within Lilly Genetic Medicine/RNA Therapeutics is seeking a senior experimental genomics expert to lead and execute genomics assays in support of the discovery and development of RNA medicines. This role is embedded in a high-throughput genomics screening environment that generates decisional data for siRNA and antisense oligonucleotide programs across the LGM portfolio. The successful candidate will be a hands-on experimentalist with strong technical skills in next-generation sequencing (NGS), a commitment to rigorous sample management and documentation, and a desire to contribute meaningfully to the advancement of genetic medicines.

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* Key Responsibilities:

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* + Execute and optimize NGS library preparation workflows (e.g., 3' RNA-seq, mRNA-seq, etc.) across targeted and large-scale screening campaigns, maintaining high quality and throughput

+ Track, document, and QC samples through all stages of assay development

+ Develop, troubleshoot, and refine genomics assay protocols to meet evolving program needs, including new library chemistries, multiplexing strategies, and sample input optimization

+ Maintain impeccable sample tracking, chain-of-custody documentation, and electronic lab notebook records in compliance with Lilly quality standards

+ Collaborate closely with computational genomics, medicinal chemistry, and biology colleagues to ensure experimental designs generate robust, interpretable, and decisional data

+ Participate actively in cross-functional project teams, contributing scientific perspective on assay design, data interpretation, and experimental prioritization

+ Support lab infrastructure including reagent inventory, equipment maintenance, and continuous improvement of standard operating procedures

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* Basic Qualifications:

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* + Bachelor's degree in genomics, molecular biology, biochemistry, genetics, or a related discipline with a minimum of 3+ years of relevant laboratory experience; OR Master's degree in genomics, molecular biology, biochemistry, genetics, or a related discipline with a minimum of 1+ years of relevant laboratory experience

+  _Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1_

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* Preferred Qualifications:

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* + Demonstrated hands-on experience with NGS library preparation, quality control (Qubit, Tape Station/Bioanalyzer, qPCR-based quantification), and sequencer operation

+ Strong organizational skills with meticulous attention to sample management, documentation, and experimental reproducibility

+ Ability to work effectively in a fast-paced, team-oriented research environment generating high-quality decisional data at scale

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Experience with high-throughput or pooled screening workflows in a pharmaceutical or genomics core environment

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Experience with singe cell genomics or spatial transcriptomics data

+ Familiarity with RNA therapeutics biology (siRNA, ASO) and associated transcriptomic readouts

+ Bioinformatics experience including comfort with command-line tools, scripting (R, Python), and/or analysis of NGS data (alignment, QC metrics, differential expression)

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Experience with automation platforms (e.g., Hamilton, Beckman) for library preparation or sample handling

+ Track record of method development or assay optimization in a research or development setting

+ Experience using and developing ELN based documentation tools.

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