Postdoctoral Research Fellow

Postdoctoral Research Fellow

The Morini Laboratory at the Center for Genomic Medicine at Massachusetts General Hospital (MGH) and Harvard Medical School is seeking a highly motivated Postdoctoral Research Fellow to join our translational research team focused on developing novel therapeutic strategies for Familial Dysautonomia (FD), a rare neurodegenerative disease.

This project aims to evaluate the efficacy of gene editing approaches and small-molecule splicing modulators in a mouse model of FD. The successful candidate will lead in vivo studies and apply molecular, cellular, and genomic approaches to assess therapeutic outcomes.

We are seeking a creative, independent, and collaborative scientist with a strong background in molecular neuroscience, gene editing, RNA biology, or neurogenetics. Experience working with mouse models, including behavioral assays and molecular analysis of tissues, is highly desirable.

This is a unique opportunity to work at the interface of basic science and translational medicine within a collaborative and highly supportive environment. Our lab is part of the MGH/Harvard/Broad Institute ecosystem, providing access to state-of-the-art resources and a vibrant scientific community.

Duties and responsibilities:

• Design and conduct in vivo efficacy studies to test gene editing strategies and/or compounds in FD mice.
• Perform downstream analyses, including RNA/protein quantification, splicing analysis, and histological assessments.
• Lead the development and optimization of therapeutic delivery and molecular assays.
• Collaborate with internal and external researchers and contribute to mentorship of junior lab members.
• Prepare manuscripts, present findings at scientific meetings, and contribute to grant applications.

The ideal candidate should have received (or expect to receive soon) a Doctoral degree, preferred Ph.D. in neuroscience, cell or molecular biology, human genetics, biochemistry, or related field.

Qualifications

• EDUCATION:
  
  Minimum
  
  Required:
  
  Doctoral Degree
• EXPERIENCE:
  
  Required:
  
  Doctoral degree;
  Preferred:
  Ph.D. in neuroscience, molecular biology, genetics, or a related field.

Desired skills and competencies:

• Molecular biology techniques including DNA, RNA, and protein isolation and manipulation (RT-PCR, qRT-PCR, western blotting)
• Good understanding of genetic methodologies, with experience in cloning, CRISPR/Cas genetic editing techniques, genomic sequencing
• Some level of cell culture experience, including cell lines generation, transfection/transduction, selection, propagation, preservation, and phenotypic characterization
• Prior experience with rodent models, gene editing, or RNA splicing is strongly preferred.
• Some experience with microscopy imaging and immuno-cytochemistry (IHC) techniques
• Histological and immune-histochemical techniques.
• First (or co-first) author of one or more peer-reviewed scientific publications
• Excellent English verbal and written communication skills
• Able to work both independently and in a team

Interested applicants should submit their CV/Resume, Cover Letter and References to:
Dr. Elisabetta Morini EMORINIvard.edu

Please do not apply through this link.

Work Location:

185 Cambridge Street

EEO Statement:
Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at .