Postdoctoral Research Fellow

Site:
Massachusetts General Physicians Organization, Inc.

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary The salary range for this position is $70,000 to $ 71,750 annually.

Please send you CV/Resume, Cover Letter and References directly to:
Dr. Elisabetta Morini EMORINIvard.edu for this position. A linked application is not available.

The Morini Laboratory at the Center for Genomic Medicine at Massachusetts General Hospital (MGH) and Harvard Medical School is seeking a highly motivated Postdoctoral Research Fellow to join our translational research team focused on developing novel therapeutic strategies for Familial Dysautonomia (FD), a rare neurodegenerative disease.

This project aims to evaluate the efficacy of gene editing approaches and small-molecule splicing modulators in a mouse model of FD. The successful candidate will lead in vivo studies and apply molecular, cellular, and genomic approaches to assess therapeutic outcomes.

We are seeking a creative, independent, and collaborative scientist with a strong background in molecular neuroscience, gene editing, RNA biology, or neurogenetics. Experience working with mouse models, including behavioral assays and molecular analysis of tissues, is highly desirable.

This is a unique opportunity to work at the interface of basic science and translational medicine within a collaborative and highly supportive environment. Our lab is part of the MGH/Harvard/Broad Institute ecosystem, providing access to state-of-the-art resources and a vibrant scientific community.

Duties and responsibilities:

Design and conduct in vivo efficacy studies to test gene editing strategies and/or compounds in FD mice.

Perform downstream analyses, including RNA/protein quantification, splicing analysis, and histological assessments.

Lead the development and optimization of therapeutic delivery and molecular assays.

Collaborate with internal and external researchers and contribute to mentorship of junior lab members.

Prepare manuscripts, present findings at scientific meetings, and contribute to grant applications.

The ideal candidate should have received (or expect to receive soon) a Doctoral degree, preferred Ph.D. in neuroscience, cell or molecular biology, human genetics, biochemistry, or related field.

Qualifications

EDUCATION:

Minimum

Required:

Doctoral Degree

EXPERIENCE:

Required:

Doctoral degree

Preferred:
Ph.D. in neuroscience, molecular biology, genetics, or a related field.

Desired skills and competencies:

Molecular biology techniques including DNA, RNA, and protein isolation and manipulation (RT-PCR, qRT-PCR, western blotting)
Good understanding of genetic methodologies, with experience in cloning, CRISPR/Cas genetic editing techniques, genomic sequencing

Some level of cell culture experience, including cell lines generation, transfection/transduction, selection, propagation, preservation, and phenotypic characterization

Prior experience with rodent models, gene editing, or RNA splicing is strongly preferred.

Some experience with microscopy imaging and immuno-cytochemistry (IHC) techniques

Histological and immune-histochemical techniques.

First (or co-first) author of one or more peer-reviewed scientific publications

Excellent English verbal and written communication skills

Able to work both independently and in a team Interested applicants should submit their CV/Resume, Cover Letter and References to:
Dr. Elisabetta Morini EMORINIvard.edu Please do not apply through this link.

Additional Job Details (if applicable)
Remote Type Hybrid Work  Location
185 Cambridge StreetEEO Statement:1300 Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without…