Research Associate II, CRISPR-X - LNP

Overview

CRISPR Therapeutics is a biopharmaceutical company focused on developing transformative gene-based medicines for serious human diseases. The Company has evolved from a pioneering research-stage organization into an industry leader, with approvals including CASGEVY® (exagamglogene autotemcel [exa-cel]), the world’s first CRISPR-based therapy, for eligible patients with sickle cell disease and transfusion-dependent beta thalassemia. CRISPR Therapeutics is advancing a broad pipeline across hemoglobinopathies, cardiovascular, autoimmune, oncology, regenerative medicine and rare diseases.

The Company is advancing gene editing through SyNTase™ editing and collaborates with leading biopharmaceutical partners. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with a U.S. subsidiary in the United States, and R&D operations in Boston, MA and San Francisco, CA.

We are seeking a highly motivated Research Associate II to support the design, development, and optimization of novel lipid nanoparticle (LNP) formulations to advance our non-viral delivery platform for hepatic and extra-hepatic tissues, enabling next-generation genome editing therapies from discovery through clinical translation. The ideal candidate will bring hands-on expertise in LNP formulation development, scale-up, analytical characterization, chemistry, and process development, with a strong passion for innovation in nucleic acid delivery technologies.

This individual will join the CRISPR-X division to contribute to platform technology innovation and preclinical therapeutic programs. In this role, the candidate will work cross-functionally to develop and characterize advanced delivery systems for emerging editing modalities, helping drive transformative gene editing therapies toward patients with unmet medical needs.

• Design, optimize, characterize, and execute lipid nanoparticle (LNP) formulations across a diverse range of lipid compositions and therapeutic payloads with minimal supervision.
• Apply hands-on expertise in LNP analytical characterization techniques, including Ribo Green assays, DLS, NanoFCM, NTA, TFF, endotoxin testing, and HPLC, as well as molecular biology methods such as DNA/RNA extraction, ELISA, SDS-PAGE, PCR, and Western blotting.
• Generate high-quality, reproducible datasets and maintain accurate, detailed experimental documentation in electronic laboratory notebooks (ELNs).
• Perform mammalian cell culture and support in vitro studies, including transient transfection and electroporation in established cell lines. Collaborate cross-functionally with process development, analytical, and in vivo teams to support reproducible manufacturing processes and advance programs toward clinical development.
• Contribute to platform innovation by investigating LNP mechanisms of action to improve delivery efficiency, therapeutic potency, and formulation stability.
• Present experimental results, technical findings, and project updates to cross-functional teams and broader organizational audiences.
• Effectively manage multiple priorities and projects in a fast-paced, highly collaborative research environment.

• BS or MS in Chemistry, Chemical Engineering, Biochemistry, or a related scientific discipline.
• Relevant industry or academic research experience:
  • Research Associate II: 2-5+ years with a bachelor’s degree or 0-2+ years of relevant experience with a master’s degree
• Hands-on experience in lipid nanoparticle (LNP) formulation and analytical characterization for nucleic acid and targeted delivery applications.
• Strong understanding of drug delivery systems and gene editing therapeutics.
• Demonstrated ability to work independently while contributing effectively within a fast-paced, results-driven, and collaborative research environment.
• Highly organized with strong scientific rigor, problem-solving skills, and attention to detail.

• Experience with high-throughput formulation screening and knowledge of microfluidic mixing process.
• Prior experience of ionizable lipid design, bioconjugation, and process development preferred.
• Prior experience with scale-up and…