Raven StealthCo- Scientist, Conjugation Chemistry

About Raven

We are Raven, RA Capital’s healthcare incubator. From discovery to delivery, whether we incubate, accelerate or rejuvenate, Raven’s goal is to turn scientific breakthroughs into transformative therapies and get them quickly, safely and efficiently to the patients that need them most. Raven’s experienced scientists, operators, and healthcare innovators have deep sector expertise across therapeutics, diagnostics, devices and services. They have brought hundreds of therapeutics into development, managed hospital systems, optimized clinical trials and navigated payor and regulatory systems to deliver patient impact - and they are ready to work with you.

We are in the discovery stage and will invest heavily in its emerging platform for oligonucleotide delivery. Our disease focus offers strong translatability from animal models to humans, which provides a potentially rapid and efficient path to the clinic. Given our recent funding and commitment to building a first‑in‑class platform with clear therapeutic targets and indications, we are recruiting a Scientist, Conjugation Chemistry.

This individual will be responsible for technical planning and production of our antibody/peptide‑oligonucleotide conjugates for our targeted delivery platform.

The Scientist, Conjugation Chemistry will report directly to the Director of Oligonucleotide and Conjugation Chemistry and will interface frequently with members of the delivery group and cross‑functional teams to advance oligonucleotide therapeutic programs. This individual will help define and execute the chemical strategy to produce oligonucleotide conjugates in an efficient and timely manner. As a lab‑based role, this person will assist in the implementation and use of scientific and analytical equipment to yield high‑quality conjugate materials.

• Define and implement reproducible technical protocols to develop oligonucleotide conjugates for biological evaluation in our targeted delivery platform.
• Develop conjugation strategies (cysteine, lysine, glycan, site‑specific, etc.) to yield stable and well‑characterized oligonucleotide conjugates.
• Design and incorporate linker chemistries for oligonucleotide conjugates to optimize PK/PD properties.
• Assist in internal lab build, procuring and utilizing equipment to enable conjugation and purification of antibody/peptide‑oligonucleotide conjugates.
• Assist analytical scientists in developing methods (HPLC, MS, etc.) to characterize oligonucleotide conjugates.
• Work hand‑in‑hand with protein engineers and biologists to ensure timely and adequate preparation of oligonucleotide conjugates for biological evaluation as well as contribute to the design of in vitro and in vivo studies.
• Contribute to intellectual property around oligonucleotide‑conjugates for the company.

• A degree (BS/MS/PhD) in chemistry, protein engineering, or a related discipline with 3+ years of experience working with antibody, protein, or peptide conjugates in the biopharmaceutical industry.
• Experience working with oligonucleotide‑based therapeutic modalities such as siRNAs and ASOs is a plus.
• Adept in state‑of‑the‑art conjugation (cysteine‑maleimide, click chemistry, site‑specific, etc.), purification (HPLC, SEC, IEX, etc.), and analytical (HPLC, LC‑MS, etc.) methods to prepare oligonucleotide conjugates.
• While demonstrating creativity to contribute to the development of novel delivery systems, this individual must also be process‑ and detail‑oriented to ensure production of high‑quality oligonucleotide conjugates.
• Imperative that this individual be an effective communicator and proven team‑player, with the ability to operate independently in a laboratory setting.

The Scientist, Conjugation Chemistry must be a doer with the ability to generate high‑quality conjugate materials efficiently and effectively, while contributing to the interpretation of complex scientific data. This person should have direct experience working on antibody, protein, or peptide‑based conjugation platforms with a significant background in chemistry and/or protein engineering. They must demonstrate strong technical skills, turning novel ideas from paper into rigorous results.

Based on‑site at the company’s headquarters in Cambridge, MA.

Base salary range: $120,000 – $170,000 USD.