Director, DMPK&M

Job Description

Director, Drug Metabolism, Pharmacokinetics & Modeling (DMPK&M) within the Gastrointestinal and Inflammation (GI2) Therapeutic Area Unit. This role provides strategic leadership across gastrointestinal and inflammatory disease programs, integrating ADME, pharmacokinetics/pharmacodynamics, and quantitative modeling to drive decisions from early discovery through clinical development.

Are you looking for a patient‑focused, innovation‑driven company that will inspire you and empower you to shine?

• Provide strategic leadership for DMPK&M across multiple GI2 programs
• Serve as the DMPK&M representative on cross‑functional research or global project teams
• Design and execute ADME strategies supporting IND and clinical progression
• Drive quantitative decision‑making using modeling approaches (PBPK, mechanistic PK/PD, early feasibility analysis)
• Enable prediction of human PK, dose selection, tissue exposure, and target engagement
• Identify and mitigate risks such as DDI, variability, and absorption challenges
• Contribute to regulatory submissions and health authority interactions
• Collaborate cross‑functionally with clinical pharmacology, safety, CMC and regulatory
• Manage resources and plan budgets efficiently for DMPK&M
• Mentor junior scientists and foster a data‑driven culture
• Contribute to publications and external scientific engagement

• PhD with 10+ years experience, or MS with 16+, or BS with 18+
• Experience across drug discovery and development
• Proven leadership and experience working on cross‑functional project teams
• Strong background in ADME, translational science and human PK prediction
• Experience collaborating with pharmacometrics or QSP teams
• Knowledge of regulatory expectations (FDA, EMA, ICH)
• Ability to integrate PK, PD, safety, and efficacy data

• Experience in applying quantitative frameworks such as modeling & simulation to guide strategic decisions
• Experience in GI2 disease area is a plus

• Strategic thinker with strong scientific judgment
• Ability to lead in a matrixed environment
• Strong communication skills
• Collaborative mindset
• Ability to prioritize and drive decisions

Location:

Boston, MA

U.S. Base Salary Range: $ – $

U.S. based employees may be eligible for short‑term and/or long‑term incentives. Benefits include medical, dental, vision insurance, a 401(k) plan with company match, short‑term and long‑term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, well‑being benefits, up to 80 hours of sick time per calendar year, and up to 120 hours of paid vacation for new hires.

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.