Senior Director; Senior Principal Scientist), Translational Medicine, Immunology

Senior Principal Scientist (Senior Medical Director)

Translational Medicine, Immunology in our Research & Development Division is responsible for planning and managing an important inflection point in the drug development process, working closely with scientific, regulatory, statistical, and modeling colleagues across the organization to translate the benchtop science of preclinical discovery into compounds ready for assessment in large clinical populations.

We are seeking a highly qualified physician‑scientist with a proven track record in both the pharmaceutical industry and independent academic research.

Location: Boston, MA;
West Point, PA;
Upper Gwynedd, PA;
Rahway, NJ;
San Francisco, CA (other locations may be considered).

• Contributing to the identification of novel targets by partnering with discovery research teams to bring a clinical insight into the earliest stages of target identification and validation, and executing clinical studies to evaluate the relevance of potential targets to human disease in order to justify investment in full development.
• Development of biomarker strategies through cross‑functional teams that provide line‑of‑sight from First‑in‑Human studies through clinical Proof‑of‑Concept.
• Development and execution of the early clinical development strategy for novel therapy/Immunology programs from Preclinical Candidate approval through clinical Proof‑of‑Concept (Phase 2a).
• Development and execution of clinical pharmacology strategies for late‑stage development programs from Proof‑of‑Concept (Phase 2a) through worldwide marketing application.
• Providing clinical expertise for the identification and validation of novel targets, including the design of preclinical and/or clinical pharmacology experiments to validate targets and/or pathways.
• Safe and timely execution of Phase I studies; close collaboration with internal and external clinical study support staff and scientists.
• Providing clinical pharmacology support for programs through worldwide marketing application filing.
• Clear, timely communication and interpretation of study results to governance, functional area experts and development review committees.
• Contribute to assessment of internal and external opportunities identified by Business Development and Licensing, interfacing with key functions across the organization.

• Key member of an early development team, providing leadership in designing and executing early clinical development strategy.
• Develop and execute early clinical strategy for novel Immunology assets and therapeutics, including authoring initial clinical and biomarker plans for Lead Optimization programs and early clinical development plans for Preclinical Candidate molecules.
• Conduct Phase 1a/b trials and clinical pharmacology studies for programs in Phases I through IV of development.
• Conduct studies to validate clinical platforms utilizing established and novel biomarkers, including imaging.
• Provide clinical pharmacology support for worldwide marketing application filing.
• Provide clear, timely communication of study results.

• Education: Minimum requirement MD or MD/PhD.
• Experience: At least 5‑year experience in the pharmaceutical industry in clinical research, preferably in immunology clinical research, including translational research.
• Track record: Proven track record in clinical research in the pharmaceutical industry; proven track record in clinical care or management of clinical problem‑solving, preferably in Dermatology.
• Scholarly record: Demonstrated record of scientific scholarship and achievement.
• Research expertise: In any immunology field preferred.
• Skills: Strong interpersonal, writing and presentation skills; ability to function in a team environment.

• Academic Research
• Clinical Studies
• Clinical Trial Development
• Dermatology, Gastroenterology, Immunology, Rheumatology
• Drug Development, Intellectual Curiosity, Pharmaceutical Research, Scientific Publications, Scientific Research, Translational Research

Salary range: $ – $. Successful candidate will be eligible for annual bonus and long‑term…