Principal Biologist

Responsibilities

• Design and execute cell-based pharmacology assays to evaluate proximity-inducing compounds (degraders, molecular glues, stabilizers)
• Manage CRO relationships for outsourced assays and run high-priority experiments in-house
• Characterize compound activity profiles: dose-response, kinetics, selectivity, mechanism of action, and SAR at the cellular level
• Build and validate disease-relevant cellular models (engineered cell lines, primary cells, co-culture systems) for target validation and translational pharmacology
• Develop and optimize quantitative assay readouts including high-content imaging, flow cytometry, reporter systems, and multiplexed approaches
• Collaborate with computational scientists and the XLMS platform team, providing biological feedback to improve ML model predictions and data generation priorities
• Prepare data packages for internal decision-making, BD/partnership discussions, and due diligence

• PhD in cell biology, pharmacology, molecular biology, or a related discipline
• 3–8 years of post-PhD experience in a biotech or pharma drug discovery environment, ideally in proximity biology, targeted protein degradation, or molecular glue programs
• Deep hands‑on expertise in designing and executing cell‑based pharmacology assays (degradation assays, ternary complex formation, ubiquitination, reporter systems)
• Experience with quantitative cellular techniques: high‑content imaging, flow cytometry, AlphaLISA/HTRF, NanoBRET, Western blot, ELISA, and/or proteomics‑based approaches (TMT, global proteomics)
• Track record of working at the interface of computational predictions and experimental validation
• Comfortable working in a fast‑paced, resource‑constrained environment where you own the experimental design end to end
• Strong scientific communication skills; able to present data clearly to computational and medicinal chemistry and biology audiences.